{"id":"W1986411093","doi":"10.1038/cgt.2013.8","title":"Polymeric delivery of siRNA for dual silencing of Mcl-1 and P-glycoprotein and apoptosis induction in drug-resistant breast cancer cells","year":2013,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Gene silencing; Survivin; Small interfering RNA; Cancer research; Apoptosis; Cancer cell; Chemistry; Downregulation and upregulation; Cancer; Biology; Cell biology; Transfection; Cell culture; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002213313,0.0002334381,0.000196349,0.0002432454,0.0001856427,0.0003188864,0.0002272485,0.0003929815,0.0006827693],"category_scores_gemma":[0.0001206782,0.0001673603,0.0002113416,0.0001603303,0.0001909338,0.0002310639,0.0001972527,0.0003649766,0.0001886574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004912229,"about_ca_system_score_gemma":0.0002519123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007914345,"about_ca_topic_score_gemma":0.001363792,"domain_scores_codex":[0.9998744,0.00002008506,0.0000100772,0.00002804466,0.00003463661,0.00003271276],"domain_scores_gemma":[0.9999409,0.00001363911,0.00001788843,0.000006904625,0.00001068484,0.000009952005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004942058,0.00002015829,0.00003354031,0.00002698061,0.000004388422,0.00002768756,0.00001649158,0.0001514107,0.9976896,0.0002097007,0.00004469754,0.001725885],"study_design_scores_gemma":[0.00001736382,0.0001678224,0.0003707253,0.000002625613,0.00001515427,0.00006840209,0.000006660866,0.001234684,0.9964918,0.00002553997,0.0015953,0.000003906143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853542,0.001640507,0.01014735,0.0001768201,0.0000567837,0.00007281603,0.0001305387,0.000142867,0.00227805],"genre_scores_gemma":[0.9922251,0.0005059591,0.004431055,0.00005113594,0.000009484029,0.00004653295,0.00009290472,0.00002175247,0.002616227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007914345,"threshold_uncertainty_score":0.00356406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026599807382284,"score_gpt":0.237593589697217,"score_spread":0.2273275916233942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}