{"id":"W1986413768","doi":"10.1242/jcs.102111","title":"Amyotrophic Lateral Sclerosis Mutant VAPB Causes a Nuclear Envelope Defect","year":2012,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; Cell biology; Nuclear transport; Nucleoporin; Mutant; Cytoplasm; Nuclear pore; Inner membrane; Transport protein; Cell nucleus; Biochemistry; Gene; Mitochondrion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000929229,0.0004341135,0.0001931314,0.0002276202,0.0002427091,0.000247107,0.0002039558,0.0004323098,0.0008610414],"category_scores_gemma":[0.0001371388,0.00020572,0.0001604944,0.0001486069,0.0004214363,0.0001215417,0.0003461218,0.0004136182,0.000744596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002768924,"about_ca_system_score_gemma":0.00016014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005909464,"about_ca_topic_score_gemma":0.0007865087,"domain_scores_codex":[0.9999058,0.00001452341,0.00001098505,0.00001985926,0.00003726098,0.00001156076],"domain_scores_gemma":[0.9998916,0.00001660024,0.00003191998,0.00001157859,0.000009092189,0.00003917895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004744396,0.000009159879,0.00019765,0.00001502699,0.000004165542,0.0006378799,0.000009522588,0.00003866005,0.9984581,0.0000829983,0.00003693058,0.0004623692],"study_design_scores_gemma":[0.00009139264,0.000347957,0.01143449,0.00002326259,0.00002904027,0.01373434,0.00006835775,0.002623894,0.9655033,0.0003148186,0.005808871,0.00002038334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971899,0.0004075709,0.001277334,0.00008575164,0.00002115988,0.000009036319,0.0001809956,0.00009112609,0.000737008],"genre_scores_gemma":[0.9960247,0.0003509032,0.001540505,0.00003802169,0.000007677295,0.00001559196,0.0003251556,0.00002609977,0.001671213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008610414,"threshold_uncertainty_score":0.002880514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01096950657236966,"score_gpt":0.2151102258464846,"score_spread":0.204140719274115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}