{"id":"W1986420914","doi":"10.1016/j.ejmech.2008.03.020","title":"Steroidal lactones as inhibitors of 17β-hydroxysteroid dehydrogenase type 5: Chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities","year":2008,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Steroid; Androgen; Hydroxysteroid dehydrogenase; Testosterone (patch); Enzyme; Lactone; Dehydrogenase; Androgen receptor; IC50; Stereochemistry; Estrogen; Endocrinology; Internal medicine; Prostate cancer; Biochemistry; In vitro; Hormone; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005077067,0.0007199603,0.0003485177,0.0007217316,0.0002434672,0.0003116852,0.0004896367,0.0003089967,0.001416687],"category_scores_gemma":[0.0003363371,0.000331698,0.0003377515,0.0005328859,0.0004125316,0.0003020171,0.0002264443,0.0005579609,0.0003932748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004693276,"about_ca_system_score_gemma":0.0005653864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002602622,"about_ca_topic_score_gemma":0.005628829,"domain_scores_codex":[0.9997807,0.00006334545,0.00001987037,0.00002189801,0.00005673633,0.00005746668],"domain_scores_gemma":[0.9998456,0.0000406981,0.0000302797,0.00001838856,0.00002945896,0.00003552603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003660464,0.0005977601,0.001055389,0.0003302067,0.0000733102,0.0002630043,0.0001092678,0.001710965,0.9572275,0.001032392,0.0003992968,0.03354045],"study_design_scores_gemma":[0.0001444794,0.002404425,0.001111691,0.00001147486,0.00007199215,0.0001702165,0.00002556018,0.0004718937,0.9896904,0.00005610285,0.005827093,0.0000146535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8866903,0.08650357,0.01516772,0.0003118076,0.0002337495,0.0004076989,0.001284836,0.0002518933,0.009148433],"genre_scores_gemma":[0.9571041,0.0293817,0.005585997,0.0001161143,0.00006008747,0.0001109578,0.001244474,0.00002922283,0.006367329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002602622,"threshold_uncertainty_score":0.005174994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008245590159815654,"score_gpt":0.240265461608011,"score_spread":0.2320198714481954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}