{"id":"W1986425087","doi":"10.1111/j.1440-1681.2006.04464.x","title":"EXTENT OF RENAL EFFECT OF CYCLO‐OXYGENASE‐2‐SELECTIVE INHIBITORS IS PHARMACOKINETIC DEPENDENT","year":2006,"lang":"en","type":"article","venue":"Clinical and Experimental Pharmacology and Physiology","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Arthritis Network; University of Alberta; Merck KGaA","keywords":"Rofecoxib; Meloxicam; Celecoxib; Pharmacokinetics; Pharmacology; Excretion; Kidney; Chemistry; Renal physiology; Internal medicine; Medicine; Endocrinology; Cyclooxygenase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000426472,0.0002726075,0.0004923231,0.0001722298,0.0001002697,0.0003884209,0.0001458955,0.0002466941,0.002098487],"category_scores_gemma":[0.000648064,0.0001829776,0.0003896018,0.0001477918,0.0002290597,0.0003926222,0.0001316015,0.0004914803,0.0002988501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001905165,"about_ca_system_score_gemma":0.0002776916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003978424,"about_ca_topic_score_gemma":0.0005856242,"domain_scores_codex":[0.9996915,0.00007945691,0.00002180807,0.00004929302,0.0001211986,0.00003676898],"domain_scores_gemma":[0.9992458,0.0002415315,0.0002518032,0.000098465,0.0001041815,0.00005822875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002136188,0.0001854989,0.008538974,0.0001853413,0.0001156825,0.0001767898,0.00003012731,0.0003744365,0.9708093,0.0001499762,0.0001085736,0.01718915],"study_design_scores_gemma":[0.0001199118,0.006814624,0.2030508,0.0000227591,0.0002155954,0.001905268,0.00007487706,0.002464637,0.7814303,0.0002642308,0.003609771,0.0000272713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846468,0.007129367,0.005179624,0.0001709579,0.00004968539,0.00005923979,0.0003585091,0.00007791305,0.002327845],"genre_scores_gemma":[0.9949868,0.002061668,0.001189929,0.00006358695,0.00003185195,0.00002497247,0.0002340299,0.00001253876,0.001394619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002098487,"threshold_uncertainty_score":0.007020175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014676091860431,"score_gpt":0.3490296091552668,"score_spread":0.3388828482366625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}