{"id":"W1986440635","doi":"10.1016/j.actbio.2014.04.033","title":"Progress in developing a living human tissue-engineered tri-leaflet heart valve assembled from tissue produced by the self-assembly approach","year":2014,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; Defence Research and Development Canada; Edwards Lifesciences","keywords":"Pulsatile flow; Heart valve; Biomedical engineering; Tissue engineering; Valve replacement; Materials science; Extracellular matrix; Calcification; Stenosis; Medicine; Cardiology; Internal medicine; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009088329,0.0003232956,0.0001991199,0.0002018946,0.0001502453,0.0004118087,0.0004029444,0.0004502514,0.0007954611],"category_scores_gemma":[0.0002462042,0.00014526,0.0003766163,0.0001121423,0.0002068021,0.0002818069,0.0002181919,0.0005460505,0.0004101297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001386484,"about_ca_system_score_gemma":0.0002553434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002538709,"about_ca_topic_score_gemma":0.0003417341,"domain_scores_codex":[0.9998323,0.00003837157,0.00001936642,0.00004638485,0.00004814723,0.00001550984],"domain_scores_gemma":[0.9998066,0.00006059415,0.00003932625,0.00002569685,0.0000395314,0.00002827416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004663026,0.00008444124,0.0004446456,0.0003658416,0.0000231622,0.0001437426,0.0001390859,0.0003366831,0.9739329,0.001210437,0.0003063092,0.02296612],"study_design_scores_gemma":[0.00002054604,0.0004890076,0.002448307,0.00005169394,0.00009839488,0.0008803883,0.00005948745,0.002986139,0.9628127,0.0002221054,0.02990793,0.00002330113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6298985,0.06345063,0.2856342,0.001477166,0.0008077776,0.0002803993,0.0003631996,0.0006336877,0.01745463],"genre_scores_gemma":[0.7345177,0.03622553,0.2129254,0.0006853855,0.0002138038,0.0002169709,0.001185388,0.0001248123,0.01390497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009088329,"threshold_uncertainty_score":0.004806459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442470138508475,"score_gpt":0.3167487325019354,"score_spread":0.3023240311168507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}