{"id":"W1986441020","doi":"10.1016/j.vaccine.2008.07.017","title":"Chemically attenuated Plasmodium sporozoites induce specific immune responses, sterile immunity and cross-protection against heterologous challenge","year":2008,"lang":"en","type":"article","venue":"Vaccine","topic":"Malaria Research and Control","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Provincial Laboratory of Public Health; McGill University","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Plasmodium berghei; Plasmodium yoelii; Vaccination; Immune system; Heterologous; Biology; Virology; Immunity; Malaria; Attenuated vaccine; Plasmodium (life cycle); Immunology; Microbiology; Plasmodium falciparum; Parasite hosting; Parasitemia; Virulence; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003001756,0.000844457,0.0005533856,0.000522532,0.0002413883,0.0003737978,0.0003721045,0.0005763999,0.002021336],"category_scores_gemma":[0.0003113962,0.0003252562,0.0004232758,0.0001868091,0.0004555529,0.000252763,0.0003309841,0.001929467,0.0005707853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003590542,"about_ca_system_score_gemma":0.0003915472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004364163,"about_ca_topic_score_gemma":0.0007726262,"domain_scores_codex":[0.9997535,0.00004724455,0.00001880851,0.00003648722,0.00005802496,0.00008591348],"domain_scores_gemma":[0.9996686,0.00008184797,0.00009285927,0.00005002393,0.00003362287,0.00007315377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000758614,0.0005220711,0.0002937439,0.00008223661,0.00001381646,0.00005005062,0.00003799662,0.0002142646,0.9959776,0.0003627248,0.00009051403,0.001596529],"study_design_scores_gemma":[0.0001533669,0.002959236,0.005152302,0.00001235133,0.00005181391,0.0002712414,0.00004402681,0.000815019,0.9891194,0.0001437803,0.001269536,0.000007906583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994974,0.0004116221,0.00191954,0.0001263557,0.00008633615,0.0001140269,0.0002670477,0.0000763576,0.002024732],"genre_scores_gemma":[0.9945629,0.0003994478,0.001246377,0.00009953749,0.00005814992,0.00007809629,0.0005591016,0.00002497493,0.002971452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002021336,"threshold_uncertainty_score":0.006762087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03638316525682914,"score_gpt":0.2743648974641618,"score_spread":0.2379817322073327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}