{"id":"W1986527011","doi":"10.1007/s00262-011-1108-1","title":"Integrin alphavbeta6 promotes tumor tolerance in colorectal cancer","year":2011,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; General Hospital of People’s Liberation Army","keywords":"Colorectal cancer; Immune tolerance; Immune system; Granzyme B; CD8; Cancer research; T cell; Flow cytometry; Cytotoxic T cell; Medicine; Tumor microenvironment; Immunology; Peripheral tolerance; Cancer; Metastasis; Biology; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002628581,0.0003513036,0.0006776723,0.0003750883,0.00008614711,0.00001666888,0.0004525197,0.0002294818,0.007356045],"category_scores_gemma":[0.0000512186,0.000307544,0.000164898,0.0006150057,0.0005258134,0.0001259015,0.00009363508,0.0009405649,0.0001447729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005582281,"about_ca_system_score_gemma":0.000651665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004027024,"about_ca_topic_score_gemma":0.0005209373,"domain_scores_codex":[0.9976406,0.0001677292,0.0005410308,0.0005863259,0.000267743,0.0007965753],"domain_scores_gemma":[0.9989737,0.00006614412,0.000148895,0.0005103282,0.0002081493,0.00009275486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004325182,0.000452863,0.08216485,0.00004397972,0.0003112752,0.0002148937,0.002407853,0.000002493914,0.8414697,0.00009686805,0.0002657631,0.06824429],"study_design_scores_gemma":[0.004780482,0.0007453034,0.4056611,0.0002668946,0.0000201692,0.0001034104,0.0002144307,0.00009379938,0.5786319,0.000119887,0.009048525,0.0003140292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947674,0.04746793,0.00003155694,0.0007702591,0.0005700096,0.00100474,0.00001477768,0.0001112055,0.002355529],"genre_scores_gemma":[0.9837204,0.01164642,0.0005395674,0.001103862,0.00008860435,0.001350101,0.00001061279,0.0001002924,0.001440104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3234963,"threshold_uncertainty_score":0.9999377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03564292136173908,"score_gpt":0.3247605556447968,"score_spread":0.2891176342830578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}