{"id":"W1986558997","doi":"10.1158/0008-5472.can-04-1005","title":"Celastraceae Sesquiterpenes as a New Class of Modulators That Bind Specifically to Human P-Glycoprotein and Reverse Cellular Multidrug Resistance","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Institutes of Health","keywords":"P-glycoprotein; ABCC1; Multiple drug resistance; Efflux; Multidrug resistance-associated protein 2; Abcg2; Biochemistry; ATP-binding cassette transporter; Biology; Chemistry; Transporter; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006240146,0.0002323724,0.0004691142,0.0003523115,0.0001979411,0.00004023871,0.0002571931,0.0001658154,0.0003851822],"category_scores_gemma":[0.00006353245,0.0002008337,0.0001069389,0.0006196478,0.0002956222,0.0001098022,0.00007361918,0.0005180751,0.00004582983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002962196,"about_ca_system_score_gemma":0.000757754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00150993,"about_ca_topic_score_gemma":0.001358197,"domain_scores_codex":[0.9971358,0.0000581166,0.0003685408,0.0006390893,0.001153751,0.0006447624],"domain_scores_gemma":[0.9982252,0.00003602616,0.00007461424,0.0005937393,0.0002616255,0.00080887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001037725,0.0001484034,0.001464753,0.0005399308,0.00005726236,0.0003408945,0.001647429,0.00006688289,0.9885488,0.003670313,0.001376622,0.001100948],"study_design_scores_gemma":[0.003435235,0.0003843964,0.006631169,0.00180425,0.00004242073,0.000006883754,0.001041358,0.000001933995,0.9380094,0.002546376,0.04581416,0.0002824576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907144,0.001419201,0.0004230116,0.00443225,0.0001128972,0.001287982,0.00002853349,0.00004106787,0.001540596],"genre_scores_gemma":[0.9729034,0.0003020843,0.002737492,0.0001299596,0.0002310504,0.00007314719,0.00001129788,0.00005911504,0.02355248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05053948,"threshold_uncertainty_score":0.818976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06302614274224803,"score_gpt":0.3615455965704268,"score_spread":0.2985194538281787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}