{"id":"W1986605151","doi":"10.1371/journal.pone.0087728","title":"A Novel Acylaminoimidazole Derivative, WN1316, Alleviates Disease Progression via Suppression of Glial Inflammation in ALS Mouse Model","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario","funders":"National Institute of Biomedical Innovation","keywords":"Oxidative stress; Amyotrophic lateral sclerosis; Inflammation; SOD1; Motor neuron; Neurodegeneration; Medicine; SOD2; Pharmacology; Immunology; Spinal cord; Biology; Pathology; Endocrinology; Neuroscience; Superoxide dismutase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005600469,0.0003155259,0.0002600994,0.0001768283,0.0001087817,0.00009500962,0.0002992692,0.0002327745,0.001092938],"category_scores_gemma":[0.00004893906,0.0000811277,0.000145279,0.0001386743,0.0001388554,0.0001846919,0.00009603288,0.0005482895,0.0002252872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001371677,"about_ca_system_score_gemma":0.0002315791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009976299,"about_ca_topic_score_gemma":0.002199177,"domain_scores_codex":[0.9999629,0.000004053508,0.000003601316,0.000007179354,0.00001263972,0.000009591904],"domain_scores_gemma":[0.9999741,0.00000115736,0.000008414183,0.000001772213,0.000004405587,0.00001010634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003797688,0.0001505723,0.0001239696,0.00007870312,0.000007413303,0.00006425822,0.000008624911,0.0001092739,0.994953,0.00009568969,0.0001448138,0.003883841],"study_design_scores_gemma":[0.0002654543,0.004745629,0.004849849,0.0000170485,0.00005931826,0.0005331726,0.00003082113,0.001208944,0.9809448,0.00008921156,0.007241359,0.00001449094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926125,0.002031386,0.002401192,0.0001769644,0.00005557366,0.00005657142,0.0005097895,0.0002210752,0.001934955],"genre_scores_gemma":[0.9889129,0.002520394,0.002679921,0.0001072857,0.00001500296,0.00006105065,0.001046965,0.00001651174,0.004639929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092938,"threshold_uncertainty_score":0.003656268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0598487884516535,"score_gpt":0.2957655616989013,"score_spread":0.2359167732472478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}