{"id":"W1986608067","doi":"10.1074/jbc.m404006200","title":"Scanning Mutagenesis of ω-Atracotoxin-Hv1a Reveals a Spatially Restricted Epitope That Confers Selective Activity against Insect Calcium Channels","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada; National Science Foundation","keywords":"Mutagenesis; Insect; Epitope; Calcium; Chemistry; Biology; Cell biology; Biophysics; Biochemistry; Mutation; Genetics; Gene; Botany; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001440456,0.0003010115,0.0002308719,0.000139076,0.0001132194,0.0001979494,0.0002764606,0.0001892744,0.0006607994],"category_scores_gemma":[0.0001558985,0.0001599999,0.0002739707,0.0001646643,0.0002065451,0.00009162007,0.0001724572,0.0004160261,0.0003730185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003493991,"about_ca_system_score_gemma":0.0002089811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001310075,"about_ca_topic_score_gemma":0.001708437,"domain_scores_codex":[0.9998599,0.00003042814,0.00001653953,0.00002667074,0.00003665179,0.00002962022],"domain_scores_gemma":[0.9998518,0.00003799818,0.00005331301,0.00001639122,0.0000154966,0.00002501243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006686362,0.0000172625,0.0002135579,0.00001280474,0.000007712748,0.00007421809,0.00001331391,0.0002167559,0.9988319,0.00005551283,0.00001070777,0.0004793752],"study_design_scores_gemma":[0.00003793219,0.0002944549,0.007849978,0.00001239231,0.0000437359,0.0007307853,0.00004304589,0.00268886,0.9866582,0.00003878749,0.001591129,0.00001064812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973549,0.0001194599,0.001814004,0.0000258141,0.000006559399,0.0000189314,0.0001176038,0.00002210086,0.0005208105],"genre_scores_gemma":[0.9970067,0.0001487171,0.002031425,0.00004160924,0.000003338571,0.00001235554,0.0002385548,0.00001638507,0.0005009672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001310075,"threshold_uncertainty_score":0.002604842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04506631775026882,"score_gpt":0.2882356841921564,"score_spread":0.2431693664418876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}