{"id":"W1986629515","doi":"10.1007/s00223-013-9828-1","title":"Involvement of the Osteoinductive Factors, Tmem119 and BMP-2, and the ER Stress Response PERK–eIF2α–ATF4 Pathway in the Commitment of Myoblastic into Osteoblastic Cells","year":2013,"lang":"en","type":"article","venue":"Calcified Tissue International","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"Canadian Institutes of Health Research","keywords":"ATF4; Osteoblast; Integrated stress response; Unfolded protein response; RUNX2; Bone morphogenetic protein 2; Osteocalcin; C2C12; Cell biology; Chemistry; Internal medicine; Endocrinology; Myocyte; Endoplasmic reticulum; Biology; Alkaline phosphatase; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001738177,0.0002461998,0.0001962953,0.0003098876,0.0002475725,0.0003205029,0.0001407337,0.0002563037,0.001099457],"category_scores_gemma":[0.0001209564,0.0001637433,0.0002506119,0.000144936,0.0001994418,0.0002917425,0.0002250542,0.0003399257,0.0002188971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002566232,"about_ca_system_score_gemma":0.0003786114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007667972,"about_ca_topic_score_gemma":0.001362645,"domain_scores_codex":[0.9998783,0.00001856587,0.00001523096,0.0000153465,0.00003198355,0.00004055267],"domain_scores_gemma":[0.9999394,0.00001026504,0.00001284078,0.00000739421,0.00001011418,0.00001993632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007135249,0.00006311718,0.0008092621,0.00008696468,0.00001229377,0.0002359893,0.00003325699,0.00009177525,0.9937345,0.0005156289,0.00006565703,0.003638101],"study_design_scores_gemma":[0.00005430124,0.0002681171,0.0226254,0.00001218922,0.00003387081,0.0005643924,0.0001313998,0.0008818014,0.9713045,0.0001985785,0.003918753,0.00000660148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892117,0.00517991,0.001591922,0.0001770943,0.00004588667,0.00002650393,0.0002943051,0.00003065287,0.00344203],"genre_scores_gemma":[0.9933997,0.001528153,0.001112741,0.00004612764,0.00001354931,0.0000302532,0.0003931353,0.000005964554,0.003470336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001099457,"threshold_uncertainty_score":0.003678083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871529370764308,"score_gpt":0.2731808784732495,"score_spread":0.2544655847656064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}