{"id":"W1986644498","doi":"10.1074/jbc.m006868200","title":"Alternative Splicing in Intracellular Loop Connecting Domains II and III of the α1 Subunit of Cav1.2 Ca2+ Channels Predicts Two-domain Polypeptides with Unique C-terminal Tails","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Terminal (telecommunication); Cav1.2; Alternative splicing; Protein subunit; Loop (graph theory); Intracellular; Domain (mathematical analysis); C-terminus; RNA splicing; Biophysics; Chemistry; Cell biology; Biology; Genetics; Computer science; Combinatorics; Mathematics; Amino acid; Gene; Telecommunications; Gene isoform","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004082907,0.0001335694,0.0002551487,0.00003361159,0.00006393642,0.000007200957,0.0001510498,0.0001619327,0.00002029603],"category_scores_gemma":[0.0001263234,0.00008132268,0.00007811932,0.0001252244,0.0002043845,0.000008297873,0.0000942581,0.0002057183,4.397391e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002385913,"about_ca_system_score_gemma":0.0000497498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003311767,"about_ca_topic_score_gemma":0.000009132455,"domain_scores_codex":[0.999054,0.00007427132,0.0004252366,0.0001555698,0.0001361767,0.0001547179],"domain_scores_gemma":[0.999054,0.00004075831,0.0005495826,0.0001180233,0.0001708801,0.00006671187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005929659,0.00008592154,0.01074143,0.00002676421,0.00004645616,0.0000217606,0.0001798563,0.001655489,0.9862632,0.00001950255,0.000008307219,0.0003583419],"study_design_scores_gemma":[0.001560879,0.0005995866,0.001464181,0.0001775999,0.00001573949,0.000681033,0.0009886258,0.0004045908,0.9936491,0.0001733039,0.0001789328,0.0001063974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975474,0.0002398476,0.001729488,0.0001000166,0.00007565593,0.00008792504,0.000005599844,0.000002251363,0.0002118339],"genre_scores_gemma":[0.9992292,0.0001238553,0.0001947128,0.00003482821,0.0003020024,0.000001746876,0.000008283507,0.00000729601,0.00009808033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009277252,"threshold_uncertainty_score":0.3316243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485411320695268,"score_gpt":0.2419646638787662,"score_spread":0.2271105506718135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}