{"id":"W1986644498","doi":"10.1074/jbc.m006868200","title":"Alternative Splicing in Intracellular Loop Connecting Domains II and III of the α1 Subunit of Cav1.2 Ca2+ Channels Predicts Two-domain Polypeptides with Unique C-terminal Tails","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Terminal (telecommunication); Cav1.2; Alternative splicing; Protein subunit; Loop (graph theory); Intracellular; Domain (mathematical analysis); C-terminus; RNA splicing; Biophysics; Chemistry; Cell biology; Biology; Genetics; Computer science; Combinatorics; Mathematics; Amino acid; Gene; Telecommunications; Gene isoform","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001904389,0.0004323,0.0002160007,0.0001961198,0.0001763569,0.0003652805,0.0002557481,0.000319126,0.0008839243],"category_scores_gemma":[0.0002460585,0.0002423225,0.0005053747,0.0001758207,0.0002552854,0.0001600683,0.0001733164,0.0005953384,0.0008085365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002477896,"about_ca_system_score_gemma":0.0001786254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002101282,"about_ca_topic_score_gemma":0.0004646423,"domain_scores_codex":[0.9998317,0.00002164164,0.00001525316,0.00006521414,0.00003540222,0.00003078035],"domain_scores_gemma":[0.9996663,0.00008313439,0.000112183,0.00003972773,0.00003217311,0.00006647866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008326241,0.00001753639,0.00105266,0.00001983303,0.000008024899,0.0002978124,0.00002720947,0.00005896041,0.9970502,0.0001342385,0.00003601432,0.001214156],"study_design_scores_gemma":[0.000103818,0.0006397936,0.06099064,0.00003570957,0.000125585,0.008321063,0.0001358934,0.005374149,0.9135576,0.0005473932,0.01013562,0.00003281635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911582,0.0006289303,0.006770788,0.00006648573,0.00005198735,0.00003384194,0.0003473021,0.00004885432,0.0008934768],"genre_scores_gemma":[0.9882542,0.0004819722,0.00660364,0.0001223649,0.00005999594,0.00003409541,0.002885024,0.00002751919,0.001531123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008839243,"threshold_uncertainty_score":0.002957046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485411320695268,"score_gpt":0.2419646638787662,"score_spread":0.2271105506718135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}