{"id":"W1986659221","doi":"10.1016/j.vaccine.2008.05.018","title":"CD40L expressed from the canarypox vector, ALVAC, can boost immunogenicity of HIV-1 canarypox vaccine in mice and enhance the in vitro expansion of viral specific CD8+ T cell memory responses from HIV-1-infected and HIV-1-uninfected individuals","year":2008,"lang":"en","type":"article","venue":"Vaccine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Sanofi Pasteur; Ontario HIV Treatment Network","keywords":"Virology; Immunogenicity; Cytotoxic T cell; Biology; CD40; CTL*; CD8; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000567083,0.0005072544,0.00106465,0.0003368899,0.0003111374,0.00001715165,0.0006136609,0.0003576249,0.0003580316],"category_scores_gemma":[0.0002694401,0.0003607091,0.0001190323,0.0004876211,0.0002302135,0.0001727987,0.0002878327,0.0007396031,0.00001284049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009212083,"about_ca_system_score_gemma":0.0002818731,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04928786,"about_ca_topic_score_gemma":0.00402,"domain_scores_codex":[0.9956982,0.001895048,0.001101262,0.0006108308,0.0001189358,0.0005757123],"domain_scores_gemma":[0.9954072,0.003003661,0.0005462666,0.0008880401,0.0001177179,0.00003716636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01109165,0.0002437344,0.04564639,0.00001626787,0.0002164292,0.00002856454,0.005951223,0.00001080247,0.9347183,0.000003655122,0.001551834,0.0005211902],"study_design_scores_gemma":[0.004651963,0.0001583816,0.434836,0.00009960239,0.00004281255,0.00003031444,0.0007440083,0.000006702273,0.5581359,0.00001394137,0.001063063,0.0002173711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9509311,0.04542037,0.00001340685,0.00102918,0.0002519104,0.0007251937,0.001566758,0.00003559826,0.00002649279],"genre_scores_gemma":[0.9930188,0.005477484,0.00008143539,0.0001808027,0.00004651498,0.00004200083,0.0006830923,0.0000491936,0.0004206766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3891896,"threshold_uncertainty_score":0.9998845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008697997792868792,"score_gpt":0.2092825887201882,"score_spread":0.2005845909273194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}