{"id":"W1986665696","doi":"10.1016/j.bbamem.2014.08.008","title":"The periplasmic domain of Escherichia coli outer membrane protein A can undergo a localized temperature dependent structural transition","year":2014,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Periplasmic space; Bacterial outer membrane; Transmembrane domain; Transmembrane protein; Biophysics; Escherichia coli; Protein structure; Outer membrane efflux proteins; Inner membrane; Chemistry; Crystallography; Biochemistry; Biology; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002769095,0.0004950049,0.0004696127,0.0001000565,0.0002902024,0.0001340831,0.0006695521,0.0006288452,0.00001164627],"category_scores_gemma":[0.00004508597,0.0003526279,0.0002498242,0.0003186367,0.0006587196,0.00001036196,0.0001808783,0.0002718838,0.000004298367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002523967,"about_ca_system_score_gemma":0.0001688979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008841764,"about_ca_topic_score_gemma":0.0002488623,"domain_scores_codex":[0.9975742,0.0003205166,0.0005388456,0.0007201926,0.0003007514,0.0005454773],"domain_scores_gemma":[0.9985389,0.00003071984,0.0003118926,0.0008175793,0.0001666084,0.0001342879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007381791,0.00008671604,7.734421e-7,0.0001038098,0.0001902177,0.000001691052,0.0001883782,0.000007994247,0.9979927,0.0003454673,0.00007648263,0.0002675936],"study_design_scores_gemma":[0.001437869,0.0007619028,0.000244104,0.00004353809,0.00006165465,0.00002191953,0.0001588539,0.0001247463,0.9933155,0.0003597253,0.002998019,0.0004721641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930915,0.000127992,0.00004742419,0.005362616,0.0003130619,0.0007287926,0.0002145475,0.00005043361,0.0000635871],"genre_scores_gemma":[0.9976264,0.0002282468,0.0006739687,0.0004373825,0.0003273034,0.00007615457,0.000403674,0.00006477418,0.0001621402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004925233,"threshold_uncertainty_score":0.9998926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004572870272767011,"score_gpt":0.209490173702791,"score_spread":0.204917303430024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}