{"id":"W1986674930","doi":"10.1124/dmd.31.10.1214","title":"INFLUENCE OF P-GLYCOPROTEIN, TRANSFER CLEARANCES, AND DRUG BINDING ON INTESTINAL METABOLISM IN CACO-2 CELL MONOLAYERS OR MEMBRANE PREPARATIONS: A THEORETICAL ANALYSIS","year":2003,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Metabolite; Metabolism; Efflux; Secretion; Drug metabolism; P-glycoprotein; Caco-2; Cytochrome P450; Chemistry; Biochemistry; Biology; Cell; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001262425,0.0009641456,0.001401561,0.0007944283,0.0007171305,0.00121276,0.0008703272,0.001214022,0.002190917],"category_scores_gemma":[0.007151776,0.0007221321,0.002237292,0.0003936125,0.001164169,0.001851566,0.0007854399,0.001000156,0.0005090403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001400325,"about_ca_system_score_gemma":0.0008902441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006152132,"about_ca_topic_score_gemma":0.00181985,"domain_scores_codex":[0.9995725,0.0002079153,0.00001167237,0.00005646748,0.00006883915,0.00008257863],"domain_scores_gemma":[0.9964766,0.003088242,0.0001653074,0.0001074373,0.0001249799,0.00003746646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0006414457,0.0001566338,0.00262734,0.0003918417,0.0001586777,0.001437387,0.000255031,0.8371765,0.03559292,0.1039232,0.001380321,0.0162588],"study_design_scores_gemma":[0.00002551571,0.0001265685,0.001042096,0.00001348391,0.0001046146,0.0003091651,0.00004161777,0.9829049,0.00534885,0.009493553,0.0005625488,0.00002700636],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6490381,0.004379801,0.3006887,0.002995628,0.0001200424,0.000147443,0.000389522,0.0005070436,0.04173362],"genre_scores_gemma":[0.9868966,0.00151765,0.005807084,0.0001489121,0.00005582488,0.00008000503,0.0001004034,0.0001069941,0.005286513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006152132,"threshold_uncertainty_score":0.0122326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005547593495497871,"score_gpt":0.2342149797513921,"score_spread":0.2286673862558942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}