{"id":"W1986674930","doi":"10.1124/dmd.31.10.1214","title":"INFLUENCE OF P-GLYCOPROTEIN, TRANSFER CLEARANCES, AND DRUG BINDING ON INTESTINAL METABOLISM IN CACO-2 CELL MONOLAYERS OR MEMBRANE PREPARATIONS: A THEORETICAL ANALYSIS","year":2003,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Metabolite; Metabolism; Efflux; Secretion; Drug metabolism; P-glycoprotein; Caco-2; Cytochrome P450; Chemistry; Biochemistry; Biology; Cell; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005247251,0.0002519578,0.0006714431,0.0005031538,0.0001012601,0.00002853766,0.00006260346,0.00008954383,0.0000653637],"category_scores_gemma":[0.000045691,0.0001862041,0.0001260091,0.0008838106,0.0002193965,0.0002269627,0.000007122228,0.0002237232,0.000002365805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001508352,"about_ca_system_score_gemma":0.00006450206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001027952,"about_ca_topic_score_gemma":0.00009970381,"domain_scores_codex":[0.9983144,0.0001571461,0.0004907508,0.0004384276,0.0003284223,0.0002708198],"domain_scores_gemma":[0.9993678,0.00008686001,0.00007455133,0.0002216784,0.00008211217,0.0001670315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01012765,0.001871966,0.01003763,0.001477987,0.0006876977,0.0002045044,0.01449442,0.005058385,0.5384064,0.4152516,0.00001847055,0.00236335],"study_design_scores_gemma":[0.008712188,0.0002058497,0.1728468,0.0007415026,0.005037365,0.00005367137,0.002462873,0.001433882,0.8042926,0.002940746,0.000531463,0.0007411215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952855,0.002077243,0.001001014,0.0001488472,0.0000430731,0.0005851858,0.00003606424,0.00002911875,0.0007939669],"genre_scores_gemma":[0.9973019,0.00106194,0.00119331,0.000118775,0.00002444571,0.00006382481,0.00004000371,0.00001946134,0.0001762899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4123108,"threshold_uncertainty_score":0.7593181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005547593495497871,"score_gpt":0.2342149797513921,"score_spread":0.2286673862558942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}