{"id":"W1986688227","doi":"10.1073/pnas.0709443104","title":"Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":652,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Biotechnology Research Institute","funders":"Cancer Council Victoria; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research","keywords":"Apoptosis; Biology; Bcl-xL; Bcl-2-associated X protein; Cancer cell; Cell biology; Cancer research; Programmed cell death; Cancer; Biochemistry; Genetics; Caspase 3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007884217,0.00039853,0.000266145,0.0002415101,0.00008995752,0.0001633013,0.0002124986,0.0001995993,0.0009362543],"category_scores_gemma":[0.000062672,0.0001051244,0.000147075,0.0001183706,0.0002420562,0.0001346457,0.0001915967,0.0004098604,0.0002764437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002349588,"about_ca_system_score_gemma":0.0003126933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006324222,"about_ca_topic_score_gemma":0.001258234,"domain_scores_codex":[0.9999547,0.000006541556,0.000003607075,0.000006936461,0.00001051308,0.00001771098],"domain_scores_gemma":[0.9999684,0.000003741306,0.000008786182,0.000002615634,0.000003539637,0.00001279589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003351683,0.00009304607,0.0002081121,0.00006071976,0.00000988343,0.00007397284,0.00001254064,0.0002158811,0.992494,0.0002859376,0.0001036447,0.006106955],"study_design_scores_gemma":[0.0002428257,0.003107274,0.002749121,0.000009105838,0.00002127284,0.000397155,0.00001614614,0.0009064792,0.9888036,0.00006496386,0.003675604,0.000006568981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955178,0.00136707,0.0008598016,0.00009249275,0.00002049703,0.00005220357,0.0001403308,0.0000826166,0.001867234],"genre_scores_gemma":[0.9945869,0.00142462,0.00128094,0.00009984299,0.000008717896,0.00003466484,0.0004563538,0.00001177021,0.00209609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009362543,"threshold_uncertainty_score":0.003132045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02298152716132188,"score_gpt":0.2714060277864639,"score_spread":0.248424500625142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}