{"id":"W1986700293","doi":"10.1158/1535-7163.targ-11-c69","title":"Abstract C69: Preliminary activity of temsirolimus, an mTOR inhibitor, in patients with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix: An NCIC-CTG phase II clinical trial.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; BC Cancer Agency","funders":"","keywords":"Temsirolimus; Medicine; Response Evaluation Criteria in Solid Tumors; Internal medicine; Clinical endpoint; Progressive disease; Phases of clinical research; Oncology; Adenosquamous carcinoma; Cancer; Chemotherapy; Cervix; Adenocarcinoma; Surgery; Clinical trial; PI3K/AKT/mTOR pathway; Discovery and development of mTOR inhibitors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003941515,0.0009354192,0.0009783118,0.000264822,0.0003003098,0.0004326156,0.0004664695,0.0009611502,0.00748692],"category_scores_gemma":[0.0002998378,0.0002237959,0.0005232408,0.0003267241,0.0003355474,0.0002622421,0.0001988063,0.001829923,0.001120382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005574657,"about_ca_system_score_gemma":0.001186129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001868864,"about_ca_topic_score_gemma":0.004786796,"domain_scores_codex":[0.99989,0.00003975444,0.00000693496,0.00001826443,0.0000142603,0.00003076324],"domain_scores_gemma":[0.9998086,0.00002489451,0.0000291888,0.000009620672,0.00001176536,0.0001159555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6381706,0.03848379,0.008100257,0.00205761,0.0009346494,0.001223115,0.000263705,0.003173308,0.1319595,0.0004098824,0.0175531,0.1576705],"study_design_scores_gemma":[0.5238736,0.4322315,0.02325365,0.0001100429,0.0004508758,0.0009080379,0.00004407848,0.001496922,0.01050951,0.0001199635,0.006964529,0.00003729522],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874021,0.00345557,0.0003191284,0.0005216618,0.0001018732,0.001991806,0.001964977,0.0001711664,0.004071744],"genre_scores_gemma":[0.9874793,0.00186383,0.0009254739,0.0008589473,0.0001604124,0.001133331,0.003274105,0.00003021704,0.004274433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00748692,"threshold_uncertainty_score":0.02504623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09987743406618643,"score_gpt":0.3790143645730128,"score_spread":0.2791369305068264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}