{"id":"W1986716910","doi":"10.1038/sj.leu.2404323","title":"Restoration of shp1 expression by 5-AZA-2′-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma","year":2006,"lang":"en","type":"article","venue":"Leukemia","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"University of Alberta; Hospital Research Foundation","keywords":"Anaplastic lymphoma kinase; Deoxycytidine; Anaplastic large-cell lymphoma; Downregulation and upregulation; Cancer research; Lymphoma; Biology; Internal medicine; Medicine; Genetics; Cancer; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770688,0.0002514336,0.0004118766,0.0003783276,0.0003315725,0.000451717,0.0003435213,0.0003411518,0.001553402],"category_scores_gemma":[0.000195612,0.0002843183,0.0002639762,0.000297001,0.0003789391,0.0002126074,0.000177054,0.0009289627,0.0004570291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005215157,"about_ca_system_score_gemma":0.0003155909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001111392,"about_ca_topic_score_gemma":0.001983925,"domain_scores_codex":[0.9997936,0.00003346481,0.0000224145,0.00003009856,0.0000546267,0.00006583195],"domain_scores_gemma":[0.9998074,0.00005712932,0.00004223917,0.00002932512,0.00001256191,0.00005147155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003590784,0.00004475271,0.0003313609,0.00002815931,0.000007971033,0.0002249849,0.000009443834,0.00005744614,0.9978518,0.0001508964,0.00009649859,0.0008376059],"study_design_scores_gemma":[0.00008053201,0.0003600002,0.02240706,0.000004416013,0.00003416502,0.001668053,0.00004817099,0.001417165,0.971072,0.0001032191,0.00279859,0.000006643986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945564,0.002489809,0.001003223,0.0001339267,0.00005381668,0.00001647595,0.0003988858,0.0000935674,0.001253931],"genre_scores_gemma":[0.9979362,0.0004210876,0.0003759606,0.0000279424,0.00001327043,0.00001780048,0.0003717044,0.00001111705,0.0008247448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553402,"threshold_uncertainty_score":0.005196691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007082090437612535,"score_gpt":0.2267968692760425,"score_spread":0.2197147788384299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}