{"id":"W1986717702","doi":"10.1021/ja9010578","title":"Crystal Structures of Cyclohexanone Monooxygenase Reveal Complex Domain Movements and a Sliding Cofactor","year":2009,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Kansai University; McGill University","keywords":"Chemistry; Flavin group; Cofactor; Flavoprotein; Stereochemistry; Catalytic cycle; Monooxygenase; Cyclohexanone; Active site; Substrate (aquarium); Oxidoreductase; Catalysis; Enzyme; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001066602,0.0002528589,0.0002911191,0.00007968213,0.0002691805,0.0005547011,0.0003919084,0.0004376908,0.0009170145],"category_scores_gemma":[0.0003247131,0.0002220563,0.0001210442,0.0001817731,0.0002335,0.0002754432,0.0002123623,0.001021195,0.0001415399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000734457,"about_ca_system_score_gemma":0.0003492671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005345664,"about_ca_topic_score_gemma":0.008911261,"domain_scores_codex":[0.9999282,0.000008197333,0.000003039294,0.00001666032,0.00002731517,0.0000165884],"domain_scores_gemma":[0.9999229,0.00001958145,0.00001558383,0.000005781424,0.00001335411,0.0000227635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001552064,0.0005944832,0.02593923,0.0004912855,0.0002619242,0.00265382,0.00116606,0.02501498,0.8998515,0.00786581,0.007314146,0.02729465],"study_design_scores_gemma":[0.001317942,0.00109167,0.2126735,0.0001428273,0.000471366,0.00403396,0.002610995,0.2964453,0.4100796,0.00615296,0.06476763,0.0002123393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966856,0.0008670487,0.0007656255,0.0002549595,0.00001603849,0.000006813174,0.0001678818,0.0000603937,0.001175683],"genre_scores_gemma":[0.9950897,0.0007628718,0.001762598,0.0000666609,0.000006711466,0.000007451507,0.0009447339,0.0000157725,0.00134344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005345664,"threshold_uncertainty_score":0.01062912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009377611605708458,"score_gpt":0.2529506659115757,"score_spread":0.2435730543058672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}