{"id":"W1986717702","doi":"10.1021/ja9010578","title":"Crystal Structures of Cyclohexanone Monooxygenase Reveal Complex Domain Movements and a Sliding Cofactor","year":2009,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Kansai University; McGill University","keywords":"Chemistry; Flavin group; Cofactor; Flavoprotein; Stereochemistry; Catalytic cycle; Monooxygenase; Cyclohexanone; Active site; Substrate (aquarium); Oxidoreductase; Catalysis; Enzyme; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001025435,0.00009019399,0.0002127364,0.000008273665,0.00004281983,0.00001021204,0.00016703,0.00004140598,0.000003663259],"category_scores_gemma":[0.00004514419,0.00006038178,0.0002101437,0.0001007701,0.0001185072,0.000004944558,0.00006471916,0.00009572476,2.836006e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002171628,"about_ca_system_score_gemma":0.00002267937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005633997,"about_ca_topic_score_gemma":3.068793e-7,"domain_scores_codex":[0.9993216,0.00003138133,0.0002732201,0.0001047947,0.0001607603,0.0001082767],"domain_scores_gemma":[0.9991838,0.00001010476,0.0005289211,0.0001395334,0.00008000849,0.00005764713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005692386,0.00005101108,0.001005324,0.000005917907,0.00007551839,2.040171e-7,0.0001143853,0.00002222965,0.9951384,0.000007107778,0.003190978,0.0003320213],"study_design_scores_gemma":[0.0005090158,0.0002566999,0.016318,0.00001230591,0.00002851307,0.00002108691,0.0004555063,0.00003428977,0.9811577,0.0001357705,0.0009884946,0.00008263031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992478,0.0001468725,0.0002802749,0.0002310904,0.00001969703,0.00004529494,0.000009761879,0.000001220131,0.00001802239],"genre_scores_gemma":[0.9966307,0.0001078673,0.00248405,0.0006302071,0.000116462,3.340729e-7,0.000009240914,0.000006113723,0.00001502413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01531268,"threshold_uncertainty_score":0.2462297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009377611605708458,"score_gpt":0.2529506659115757,"score_spread":0.2435730543058672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}