{"id":"W1986763134","doi":"10.1158/1535-7163.targ-09-a185","title":"Abstract A185: Phase I clinical, pharmacokinetic, and pharmacodynamic study of SB939, an oral histone deacetylase inhibitor (HDACi), in patients with advanced solid tumors","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Nausea; Vomiting; Pharmacokinetics; Pharmacodynamics; Adverse effect; Gastroenterology; Internal medicine; Peripheral blood mononuclear cell; Pharmacology; Colorectal cancer; Cmax; Cancer; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000379185,0.0008274375,0.0008631324,0.0002603579,0.0003274653,0.0006098677,0.0003314062,0.0004510479,0.004018338],"category_scores_gemma":[0.0002470302,0.0003273158,0.000638819,0.0003255013,0.0003670258,0.0003099337,0.0002329739,0.001758879,0.001288421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006504562,"about_ca_system_score_gemma":0.00101752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009842901,"about_ca_topic_score_gemma":0.001914764,"domain_scores_codex":[0.9998672,0.00003697776,0.000009325595,0.00002949328,0.00002439521,0.00003259134],"domain_scores_gemma":[0.9998419,0.00001401949,0.00003105831,0.00001270005,0.00001433619,0.0000859087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2903179,0.06174478,0.02783397,0.001207861,0.00141676,0.0008628115,0.0004226783,0.005030743,0.3446323,0.0005959733,0.0164307,0.2495035],"study_design_scores_gemma":[0.1247376,0.7545831,0.06140776,0.0000740783,0.0006903873,0.001132256,0.0001160376,0.002899446,0.03496147,0.0003031571,0.0190511,0.00004371187],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990721,0.00208554,0.0008878342,0.000284765,0.00007200969,0.001141303,0.002187776,0.0001495872,0.002470123],"genre_scores_gemma":[0.988751,0.00124359,0.001396611,0.0004355986,0.00006151507,0.0009230851,0.00330684,0.00003104248,0.003850771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004018338,"threshold_uncertainty_score":0.0134427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02337937597876107,"score_gpt":0.4074113515472472,"score_spread":0.3840319755684862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}