{"id":"W1986772242","doi":"10.1002/stem.1684","title":"Inability of Human Induced Pluripotent Stem Cell-Hematopoietic Derivatives to Downregulate MicroRNAs In Vivo Reveals a Block in Xenograft Hematopoietic Regeneration","year":2011,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Biology; Induced pluripotent stem cell; Haematopoiesis; Stem cell; Cell biology; Hematopoietic stem cell; Bone marrow; Embryonic stem cell; Cancer research; Transplantation; Immunology; Genetics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008327002,0.0003797397,0.0005755406,0.0003595923,0.00007154516,0.00002671343,0.0005503263,0.0003256852,0.00004479991],"category_scores_gemma":[0.00001084268,0.0003830919,0.0001561163,0.0005678335,0.0001241538,0.0000156153,0.0004043059,0.0002304227,0.00002381501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001215184,"about_ca_system_score_gemma":0.0001238014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002306706,"about_ca_topic_score_gemma":0.0003596366,"domain_scores_codex":[0.9965349,0.0004781956,0.001041687,0.0008860372,0.0003890809,0.0006701335],"domain_scores_gemma":[0.9983153,0.00002809486,0.0002779425,0.0009742593,0.0001935518,0.0002108273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001343025,0.0004547522,0.005888168,0.0004654657,0.00002338776,0.00002157352,0.002477478,0.0001351785,0.9900872,0.00003950361,0.0001305879,0.0001424317],"study_design_scores_gemma":[0.0009207539,0.000554319,0.004063946,0.0001844187,0.00001114528,0.000009860618,0.00106707,0.00001843224,0.9925619,0.0001288831,0.00010586,0.0003734359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969527,0.0003819063,0.00006981109,0.00006794935,0.00008691108,0.001413019,0.00002116304,0.00001575353,0.000990795],"genre_scores_gemma":[0.9978015,0.00004720333,0.000493034,0.00004644335,0.00003254821,0.0001296082,0.00001084736,0.00005126253,0.001387486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002474704,"threshold_uncertainty_score":0.9998621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02727135278170007,"score_gpt":0.2636896934263384,"score_spread":0.2364183406446383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}