{"id":"W1986772242","doi":"10.1002/stem.1684","title":"Inability of Human Induced Pluripotent Stem Cell-Hematopoietic Derivatives to Downregulate MicroRNAs In Vivo Reveals a Block in Xenograft Hematopoietic Regeneration","year":2011,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Biology; Induced pluripotent stem cell; Haematopoiesis; Stem cell; Cell biology; Hematopoietic stem cell; Bone marrow; Embryonic stem cell; Cancer research; Transplantation; Immunology; Genetics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002777181,0.0003282239,0.0002689207,0.000219383,0.00008211814,0.0002708335,0.0001691333,0.0001895785,0.001478435],"category_scores_gemma":[0.0001693928,0.0001653908,0.0002062767,0.0001018749,0.0002108229,0.0001740204,0.000118235,0.0006646598,0.000508806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001449825,"about_ca_system_score_gemma":0.0002147982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002955632,"about_ca_topic_score_gemma":0.0004531825,"domain_scores_codex":[0.9997851,0.00003832364,0.00003173465,0.000041466,0.00007454881,0.00002887969],"domain_scores_gemma":[0.9997572,0.00008591085,0.00005903682,0.0000454492,0.00001579656,0.00003652977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002624811,0.00001977788,0.00006786816,0.00001167575,0.000003671277,0.00001751191,0.000005149931,0.00004461144,0.9990008,0.00007911742,0.00002608627,0.0006974771],"study_design_scores_gemma":[0.000003023945,0.0001280376,0.00061321,0.0000015456,0.000005735047,0.00008750947,0.000005161998,0.0003927685,0.9980468,0.00001765458,0.0006976111,0.000001051934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859973,0.001158766,0.009757166,0.00009321036,0.00004985614,0.00005718308,0.0007941852,0.0002595354,0.001832787],"genre_scores_gemma":[0.9893072,0.0006701725,0.004058562,0.00005300017,0.000007755025,0.00004805165,0.001298702,0.00008237435,0.004474027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001478435,"threshold_uncertainty_score":0.004945874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02727135278170007,"score_gpt":0.2636896934263384,"score_spread":0.2364183406446383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}