{"id":"W1986775700","doi":"10.1021/ac035335o","title":"Characterization of the Binding Site for Inhibitors of the HPV11 E1−E2 Protein Interaction on the E2 Transactivation Domain by Photoaffinity Labeling and Mass Spectrometry","year":2004,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Transactivation; Photoaffinity labeling; Mass spectrometry; Characterization (materials science); Binding site; Combinatorial chemistry; Chromatography; Nanotechnology; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002056877,0.0003822231,0.0003197083,0.000176009,0.0002063483,0.0002582976,0.0003336902,0.0003185576,0.001062196],"category_scores_gemma":[0.000261606,0.0001932447,0.0002096777,0.0001580025,0.0001836474,0.0001528686,0.0001215648,0.0004658119,0.0005352576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004319983,"about_ca_system_score_gemma":0.0002570969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00109746,"about_ca_topic_score_gemma":0.001470293,"domain_scores_codex":[0.9998541,0.00002219948,0.000006693201,0.00002936203,0.0000584788,0.00002915899],"domain_scores_gemma":[0.999869,0.00004561861,0.00003358525,0.00001689522,0.00002010001,0.00001466786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005136113,0.00001494834,0.00007282386,0.000009956713,0.000002934614,0.00001514881,0.000004909715,0.0001221261,0.9991688,0.00004464597,0.000008366565,0.0004840422],"study_design_scores_gemma":[0.00000828151,0.00006950305,0.0008572966,0.000001250951,0.000005926351,0.00006440921,0.000003237218,0.0006032022,0.9975212,0.00001139304,0.0008520325,0.000002133138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809948,0.00126635,0.01530848,0.00009394628,0.00001322325,0.00007152846,0.0003310778,0.0000727638,0.001847847],"genre_scores_gemma":[0.9828423,0.001133711,0.01118627,0.00007228263,0.000007445783,0.00006680842,0.0008504617,0.00003864894,0.003802142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00109746,"threshold_uncertainty_score":0.003553391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00906396817616191,"score_gpt":0.2387300733134808,"score_spread":0.2296661051373188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}