{"id":"W1986775700","doi":"10.1021/ac035335o","title":"Characterization of the Binding Site for Inhibitors of the HPV11 E1−E2 Protein Interaction on the E2 Transactivation Domain by Photoaffinity Labeling and Mass Spectrometry","year":2004,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Transactivation; Photoaffinity labeling; Mass spectrometry; Characterization (materials science); Binding site; Combinatorial chemistry; Chromatography; Nanotechnology; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001888695,0.0001058526,0.0001043942,0.00001162633,0.00008906777,0.0000152581,0.0001620835,0.0001440187,0.00001209108],"category_scores_gemma":[0.0002021494,0.00006083016,0.0001208192,0.0001780612,0.0001560575,0.000004719045,0.00004936826,0.0001924658,3.664042e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002889687,"about_ca_system_score_gemma":0.00004143322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007397192,"about_ca_topic_score_gemma":9.465338e-7,"domain_scores_codex":[0.9992303,0.00003350679,0.0001965537,0.0002077406,0.0001889408,0.0001429723],"domain_scores_gemma":[0.9995152,0.00002789484,0.0001177326,0.0002360104,0.00006783139,0.00003533747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001001364,0.00006600995,0.000123359,0.00007921505,0.00003562081,7.197198e-8,0.0000173161,0.00000422681,0.9994439,0.00003771899,0.00002596322,0.000066436],"study_design_scores_gemma":[0.0003380836,0.0000527863,0.00009821935,0.00008190864,0.0000191832,0.00000144389,0.00004007961,0.00007566259,0.9987115,0.0001580427,0.0003527112,0.00007040234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963222,0.00002328711,0.001777835,0.001313369,0.0000181186,0.0003189352,0.00006649102,0.000002525848,0.0001572812],"genre_scores_gemma":[0.9995087,0.0000134148,0.00007440794,0.00007796808,0.0000539901,0.00002340892,0.00006970078,0.00001108875,0.0001673574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003186506,"threshold_uncertainty_score":0.2480582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00906396817616191,"score_gpt":0.2387300733134808,"score_spread":0.2296661051373188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}