{"id":"W1986791722","doi":"10.1016/j.mib.2013.03.005","title":"The fungal Achilles’ heel: targeting Hsp90 to cripple fungal pathogens","year":2013,"lang":"en","type":"article","venue":"Current Opinion in Microbiology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Burroughs Wellcome Fund","keywords":"Biology; Hsp90; Drug repositioning; Drug resistance; Drug; Microbiology; Heat shock protein; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007631643,0.0006371418,0.0009094038,0.0002807988,0.0005119308,0.002130248,0.000651678,0.001945476,0.003620344],"category_scores_gemma":[0.000546923,0.0002376366,0.0003620959,0.0002374047,0.001213817,0.003776287,0.001353982,0.002891266,0.001813453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006455145,"about_ca_system_score_gemma":0.0004757732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003116856,"about_ca_topic_score_gemma":0.0006501358,"domain_scores_codex":[0.9997659,0.00003940979,0.00001156988,0.0000469913,0.00006779691,0.00006827472],"domain_scores_gemma":[0.9997353,0.00005751287,0.00003752903,0.00002265939,0.00005432537,0.0000926158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001533537,0.0001089229,0.0008390945,0.002233322,0.000151527,0.001782907,0.0005134553,0.002011759,0.628675,0.04289329,0.05232786,0.2669294],"study_design_scores_gemma":[0.0003088215,0.001423864,0.004847704,0.0006659008,0.000189697,0.004955733,0.002172028,0.007841867,0.2535249,0.0701926,0.6536901,0.0001867621],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2636342,0.5196186,0.06188319,0.1090131,0.01060987,0.000154294,0.0005143728,0.00116237,0.03341005],"genre_scores_gemma":[0.6328349,0.2873206,0.01637831,0.01699221,0.005152693,0.000104387,0.0003281837,0.000171336,0.04071734],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003620344,"threshold_uncertainty_score":0.01211131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02448639504878453,"score_gpt":0.3220716581242173,"score_spread":0.2975852630754328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}