{"id":"W1986792926","doi":"10.1016/j.bcp.2003.10.035","title":"The combi-targeting concept: intracellular fragmentation of the binary epidermal growth factor (EGFR)/DNA targeting “combi-triazene” SMA41","year":2004,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Victoria Hospital; Royal Victoria Regional Health Centre; McGill University","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Intracellular; DNA; Epidermal growth factor receptor; Subcellular localization; RNA; Epidermal growth factor; Biology; Cell biology; Molecular biology; Biochemistry; Chemistry; Receptor; Gene; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001813226,0.0002540648,0.000157338,0.0001708628,0.0001368274,0.0002244476,0.0002441371,0.0004068916,0.001023038],"category_scores_gemma":[0.0001334698,0.0001231715,0.0001365999,0.0001188812,0.0001856642,0.0002607427,0.0001622818,0.0004631472,0.0003954129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002694175,"about_ca_system_score_gemma":0.0001181137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001438457,"about_ca_topic_score_gemma":0.0002378127,"domain_scores_codex":[0.9999129,0.0000142325,0.000006356034,0.00002185405,0.00003098066,0.00001375403],"domain_scores_gemma":[0.9999298,0.0000126169,0.00002701465,0.000009789685,0.000009894546,0.00001081061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006969159,0.00001189263,0.00002569276,0.00002711231,0.000002564511,0.00002794919,0.00001164201,0.00004872232,0.9964523,0.0005410527,0.00008332945,0.002697938],"study_design_scores_gemma":[0.00001105506,0.00007589501,0.0001527233,0.00000121016,0.000002851743,0.0001163122,0.00000246483,0.0003284224,0.997589,0.00003841106,0.001679566,0.000002131919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9195638,0.002616554,0.06762495,0.0005364701,0.0001111532,0.0002610048,0.0003266356,0.0005894461,0.008369992],"genre_scores_gemma":[0.9724441,0.0009302955,0.01922743,0.0001275821,0.00002130357,0.0001251365,0.0002223863,0.00004150997,0.006860328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001023038,"threshold_uncertainty_score":0.003422379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007787978619138797,"score_gpt":0.2588385671271596,"score_spread":0.2510505885080208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}