{"id":"W1986803970","doi":"10.1097/qad.0000000000000424","title":"Lower prevalence of drug resistance mutations at first-line virological failure to first-line therapy with atripla vs. tenofovir + emtricitabine/lamivudine + efavirenz administered on a multiple tablet therapy","year":2014,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"Gilead Sciences","keywords":"Emtricitabine; Efavirenz; Lamivudine; Tenofovir; Virology; Drug resistance; Medicine; Resistance mutation; Drug; Reverse-transcriptase inhibitor; Pharmacotherapy; Pharmacology; Antiretroviral therapy; Human immunodeficiency virus (HIV); Internal medicine; Viral load; Biology; Virus; Genetics; Reverse transcriptase; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003713074,0.000521135,0.0007911686,0.0002608528,0.0002813896,0.00002400936,0.0002737091,0.0001556535,0.0005551883],"category_scores_gemma":[0.0003158243,0.0003356773,0.0001765972,0.0007429261,0.000169771,0.0001015559,0.00007241432,0.000228907,0.0001233421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002010093,"about_ca_system_score_gemma":0.0001140754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001501438,"about_ca_topic_score_gemma":0.0003056353,"domain_scores_codex":[0.9972742,0.000113719,0.0006351334,0.0007700969,0.0006762638,0.0005305543],"domain_scores_gemma":[0.9975705,0.00084962,0.0002452429,0.0007937305,0.0002468427,0.0002940677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.05331765,0.00803927,0.8867931,0.0007411779,0.001402747,0.0003642405,0.005470083,0.0009832872,0.005628631,0.0004400474,0.0254248,0.01139491],"study_design_scores_gemma":[0.05011633,0.02327518,0.3512827,0.001651593,0.000515863,0.0000731663,0.0001257874,0.0008706064,0.04203024,0.0002387337,0.5281865,0.001633252],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793077,0.0006074537,0.0007441389,0.01653688,0.0000951242,0.001675453,0.0001213179,0.000138967,0.0007730133],"genre_scores_gemma":[0.9433311,0.0006747483,0.007038902,0.001130166,0.0001384763,0.000325912,0.0001869506,0.00006530691,0.0471085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5355104,"threshold_uncertainty_score":0.9999095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668110883885854,"score_gpt":0.2512804643887628,"score_spread":0.2345993555499043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}