{"id":"W1986803970","doi":"10.1097/qad.0000000000000424","title":"Lower prevalence of drug resistance mutations at first-line virological failure to first-line therapy with atripla vs. tenofovir + emtricitabine/lamivudine + efavirenz administered on a multiple tablet therapy","year":2014,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"Gilead Sciences","keywords":"Emtricitabine; Efavirenz; Lamivudine; Tenofovir; Virology; Drug resistance; Medicine; Resistance mutation; Drug; Reverse-transcriptase inhibitor; Pharmacotherapy; Pharmacology; Antiretroviral therapy; Human immunodeficiency virus (HIV); Internal medicine; Viral load; Biology; Virus; Genetics; Reverse transcriptase; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003188234,0.0002410647,0.0009174026,0.0003108362,0.0001147439,0.0004263612,0.0002584405,0.0004507962,0.003658605],"category_scores_gemma":[0.004048285,0.0001443353,0.001118155,0.0001902576,0.0001728634,0.0003617571,0.0001687319,0.0006052127,0.0003213817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002189081,"about_ca_system_score_gemma":0.0003449441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001778709,"about_ca_topic_score_gemma":0.0002703778,"domain_scores_codex":[0.9984295,0.0008220613,0.000174218,0.0002914838,0.0001738393,0.0001088203],"domain_scores_gemma":[0.9973121,0.001149608,0.0007972292,0.0002060388,0.0001752849,0.0003597622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.531713,0.009749367,0.2182686,0.001946863,0.006551189,0.0002117921,0.0003246648,0.001560967,0.0231634,0.0004939983,0.00178675,0.2042295],"study_design_scores_gemma":[0.08709784,0.4052796,0.4879506,0.0003103379,0.005075349,0.0009065307,0.0001355399,0.002377628,0.007018748,0.0003827648,0.003426159,0.00003884704],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965766,0.002129974,0.0001541195,0.00007383431,0.00003558343,0.0001345176,0.0001709757,0.000008958715,0.0007154386],"genre_scores_gemma":[0.999116,0.0002783841,0.0001449731,0.00007136859,0.00001976293,0.00005749501,0.000149185,0.000001904895,0.0001609059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003658605,"threshold_uncertainty_score":0.0168612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668110883885854,"score_gpt":0.2512804643887628,"score_spread":0.2345993555499043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}