{"id":"W1986804594","doi":"10.1016/j.bpj.2014.11.2295","title":"Identification of Major FKBP12 Binding Determinants in RyR1","year":2015,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"FKBP; RYR1; Ryanodine receptor; Binding site; Chemistry; Biology; Cell biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002555547,0.00007379041,0.0001024439,0.00004526543,0.00002347087,0.00001984889,0.0001767545,0.00006231493,0.000003533539],"category_scores_gemma":[0.0001877952,0.00006765902,0.00007123673,0.00009447847,0.00005226887,0.000005538473,0.00004902161,0.00008359316,0.00001674832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002117333,"about_ca_system_score_gemma":0.00008640837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003004973,"about_ca_topic_score_gemma":0.000001254708,"domain_scores_codex":[0.999235,0.00005778288,0.0002715708,0.0001311218,0.0001665787,0.0001379493],"domain_scores_gemma":[0.9994717,0.000006889451,0.0001547999,0.0001503795,0.00008892871,0.00012734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007147318,0.0001099344,0.007542443,0.000006140061,0.000008609517,0.00001428991,0.0000333575,0.00002227516,0.9911068,0.00001509864,0.0002713469,0.0007982347],"study_design_scores_gemma":[0.0005442003,0.0001106305,0.003280938,0.00002170405,0.00001075545,0.00002843118,0.00005344174,0.0001421498,0.9954733,0.0001242808,0.0001269632,0.00008324522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992257,0.00005842379,0.0003816927,0.00003038633,0.0002129568,0.0000453823,0.00001010717,0.000002785356,0.00003250652],"genre_scores_gemma":[0.9994799,0.000006486825,0.0001125498,0.00001867711,0.0003043624,0.000002865754,0.000004911374,0.0000102575,0.0000599686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004366462,"threshold_uncertainty_score":0.2759055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02369564365854383,"score_gpt":0.2946620789638632,"score_spread":0.2709664353053194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}