{"id":"W1986819368","doi":"10.1002/eji.200535079","title":"RNA interference reveals a role for TLR2 and TLR3 in the recognition of <i>Leishmania donovani</i> promastigotes by interferon–γ‐primed macrophages","year":2005,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"","keywords":"Leishmania donovani; Biology; TLR3; Proinflammatory cytokine; TLR2; TLR7; Interferon gamma; CD14; Interferon; Macrophage; Toll-like receptor; Immunology; Microbiology; Molecular biology; Innate immune system; Cell biology; Inflammation; Immune system; Visceral leishmaniasis; Biochemistry; Leishmaniasis; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001748675,0.0003878065,0.0002224106,0.0001154774,0.0001656007,0.0004062167,0.0001846322,0.0003322056,0.001389366],"category_scores_gemma":[0.0001162064,0.0001969499,0.0004096891,0.00006846196,0.0002638595,0.0001686769,0.0002069135,0.0005936844,0.0006474414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002758858,"about_ca_system_score_gemma":0.0002035475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002636658,"about_ca_topic_score_gemma":0.0003667016,"domain_scores_codex":[0.9998379,0.00002955441,0.00001296294,0.00003139382,0.00003360625,0.00005458168],"domain_scores_gemma":[0.9998868,0.00002484826,0.0000448595,0.00001317174,0.000008974124,0.00002147756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001680483,0.00001266509,0.00009137325,0.00001956219,0.000003742057,0.00003489626,0.000008289538,0.00003315825,0.9990939,0.0000939614,0.00002084077,0.0004196589],"study_design_scores_gemma":[0.00007405709,0.0003315412,0.007889346,0.00001480256,0.00003756045,0.0005872019,0.00006275219,0.001793369,0.9853458,0.0001809273,0.003672461,0.00001020164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911875,0.001492989,0.004285843,0.000251006,0.00004772288,0.00002919111,0.0003567308,0.0001420607,0.002206955],"genre_scores_gemma":[0.9950017,0.0005002507,0.002258991,0.0001943587,0.00001310034,0.00004267938,0.0004473134,0.00003855331,0.001503023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001389366,"threshold_uncertainty_score":0.004647851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02675520930075216,"score_gpt":0.2796741697812835,"score_spread":0.2529189604805314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}