{"id":"W1986819368","doi":"10.1002/eji.200535079","title":"RNA interference reveals a role for TLR2 and TLR3 in the recognition of <i>Leishmania donovani</i> promastigotes by interferon–γ‐primed macrophages","year":2005,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"","keywords":"Leishmania donovani; Biology; TLR3; Proinflammatory cytokine; TLR2; TLR7; Interferon gamma; CD14; Interferon; Macrophage; Toll-like receptor; Immunology; Microbiology; Molecular biology; Innate immune system; Cell biology; Inflammation; Immune system; Visceral leishmaniasis; Biochemistry; Leishmaniasis; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001880298,0.0001596106,0.0004809447,0.000226677,0.00005489567,0.00002575925,0.0003323397,0.00003610423,0.0000309524],"category_scores_gemma":[0.0009577799,0.000105719,0.00009265648,0.0001404469,0.0003045432,0.0001601935,0.0001266563,0.0004887579,0.00001222643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005086215,"about_ca_system_score_gemma":0.00004114155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007634112,"about_ca_topic_score_gemma":0.000008453612,"domain_scores_codex":[0.9979097,0.0006688586,0.0007958938,0.0001726832,0.0001729803,0.0002798672],"domain_scores_gemma":[0.9985241,0.0003845353,0.0004730286,0.000196063,0.0003737464,0.00004854229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002701864,0.0003736554,0.001470241,0.0001080554,0.0003383427,0.0000949753,0.003301281,5.721725e-7,0.7728869,0.00004242028,0.006483417,0.2121982],"study_design_scores_gemma":[0.02735596,0.0438685,0.3372845,0.004400943,0.0005341995,0.006186177,0.01402005,0.00009131716,0.5247851,0.001242213,0.03942293,0.0008081262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812549,0.01157487,0.0003877139,0.004749689,0.000074706,0.0004148264,0.00001418471,0.000007928232,0.001521154],"genre_scores_gemma":[0.9948162,0.002093346,0.002414553,0.0003628162,0.0001387144,0.000007771913,0.00000447886,0.00002606984,0.0001360526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3358142,"threshold_uncertainty_score":0.4311094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02675520930075216,"score_gpt":0.2796741697812835,"score_spread":0.2529189604805314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}