{"id":"W1986877085","doi":"10.1158/1538-7445.am2014-5011","title":"Abstract 5011: Cancer immunotherapy targeting CD47: Wild type SIRPαFc is the ideal CD47-blocking agent to minimize unwanted erythrocyte binding","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"CD47; Monoclonal antibody; Antibody; Flow cytometry; Biology; Cancer research; Fusion protein; Cancer immunotherapy; Wild type; Blocking antibody; Cell biology; Immunotherapy; Immunology; Chemistry; Immune system; Mutant; Biochemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001532274,0.000431217,0.0002524174,0.0002082942,0.000129628,0.0002592084,0.0002169146,0.0005797316,0.004917142],"category_scores_gemma":[0.00009697382,0.000104751,0.0001725663,0.000169254,0.0001929718,0.0001550712,0.00009197249,0.0006446089,0.001361934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002788523,"about_ca_system_score_gemma":0.000193176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003197778,"about_ca_topic_score_gemma":0.0002616721,"domain_scores_codex":[0.9998702,0.00001779189,0.000009409221,0.00002088937,0.0000534493,0.00002832003],"domain_scores_gemma":[0.9999371,0.00001243321,0.00001762514,0.000005830153,0.0000108985,0.00001622316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002023101,0.00006349708,0.0001577088,0.00006991856,0.000006479561,0.00003816827,0.000004871767,0.00006585578,0.9955409,0.0001431125,0.000570508,0.003136531],"study_design_scores_gemma":[0.00003741476,0.0004477941,0.001574495,0.000007796585,0.00001327897,0.000355822,0.000005075463,0.000412661,0.9911378,0.00003777018,0.005967258,0.000002848155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9605982,0.0117337,0.01057053,0.0009210912,0.0002127861,0.0001958116,0.001419239,0.0004161026,0.01393254],"genre_scores_gemma":[0.9729859,0.003828696,0.008424783,0.0003237467,0.00007591631,0.0001032031,0.00231087,0.00004948612,0.01189721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004917142,"threshold_uncertainty_score":0.01644951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06941449683637128,"score_gpt":0.3791838079166253,"score_spread":0.309769311080254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}