{"id":"W1986890759","doi":"10.1074/jbc.m202837200","title":"Modular Arrangement and Secretion of a Multidomain Serine Protease","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto","keywords":"Secretion; Serine protease; Modular design; MASP1; Serine; Protease; Chemistry; Cell biology; Computer science; Biology; Biochemistry; Programming language; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001316207,0.0002592121,0.0001104982,0.0001042495,0.00009777524,0.0002262589,0.0001272497,0.0001800895,0.0003796717],"category_scores_gemma":[0.0001860919,0.00009085177,0.000199277,0.00009482624,0.0001635894,0.0001708979,0.0002088556,0.0003400391,0.0001875619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002621558,"about_ca_system_score_gemma":0.0001818736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002172314,"about_ca_topic_score_gemma":0.0001821235,"domain_scores_codex":[0.9998823,0.00002426379,0.000009858286,0.00002497334,0.00003397829,0.00002456845],"domain_scores_gemma":[0.9998649,0.00001513731,0.00005608455,0.00002295191,0.00001595817,0.00002486168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000366878,0.000005181638,0.0002720065,0.00001016893,0.000001731336,0.00003630774,0.00000486266,0.00003398443,0.9989161,0.00004980555,0.00000939338,0.0006237199],"study_design_scores_gemma":[0.000008056411,0.0001721274,0.008346883,0.000002315012,0.00001067292,0.0005969756,0.00001555005,0.001110204,0.9887275,0.00005059257,0.0009559109,0.000003271766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968393,0.0003799339,0.002291678,0.00003982596,0.000009398089,0.000008953909,0.00007618709,0.00002552001,0.0003292304],"genre_scores_gemma":[0.996217,0.0002047614,0.002543001,0.00002091512,0.000005718945,0.000006510221,0.0002394968,0.000006279361,0.0007563442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003796717,"threshold_uncertainty_score":0.001902103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02573393013675313,"score_gpt":0.2603489816270688,"score_spread":0.2346150514903157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}