{"id":"W1986929921","doi":"10.1371/journal.pone.0083737","title":"Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Structural Genomics Consortium","funders":"Biological and Environmental Research; National Research Council Canada; Canadian Institutes of Health Research; Ontario Genomics Institute; Western Economic Diversification Canada; Wellcome Trust; Ontario Genomics; Genome Canada; GlaxoSmithKline; University of Chicago; Pfizer; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Eli Lilly and Company; Argonne National Laboratory; U.S. Department of Energy","keywords":"PRC2; EZH2; Histone H3; Methyltransferase; Chemistry; Histone methyltransferase; Biology; Cell biology; Histone; Methylation; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009473242,0.0003274644,0.0002580244,0.00009299692,0.0002351977,0.00029508,0.0004378922,0.0002922133,0.001019538],"category_scores_gemma":[0.0001801934,0.0001757721,0.0002073611,0.0001535431,0.0002101757,0.0003073452,0.0001805282,0.0007255735,0.0001739293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005428769,"about_ca_system_score_gemma":0.0002924786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002192558,"about_ca_topic_score_gemma":0.002172362,"domain_scores_codex":[0.9999567,0.00000687381,0.000001895007,0.00001132314,0.00001362642,0.000009522248],"domain_scores_gemma":[0.9999535,0.000008809015,0.00001118046,0.000003841783,0.000007333749,0.00001524637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006964227,0.0001744701,0.007759579,0.0002498866,0.00009159098,0.001442657,0.0002127179,0.01573991,0.9535717,0.006606987,0.002331297,0.01112272],"study_design_scores_gemma":[0.000415339,0.0006540425,0.0735045,0.00005704327,0.0002114896,0.002514231,0.0005601734,0.410781,0.4814533,0.007943032,0.02178826,0.0001175165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893567,0.001197295,0.006616409,0.0003546905,0.00004956867,0.00001357336,0.0002722003,0.000183702,0.001955932],"genre_scores_gemma":[0.9963884,0.0002433473,0.00218933,0.00006346883,0.000009280599,0.0000067242,0.000405498,0.00001789179,0.0006761194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002192558,"threshold_uncertainty_score":0.004359603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02116614842341164,"score_gpt":0.2236881241154174,"score_spread":0.2025219756920058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}