{"id":"W1986929921","doi":"10.1371/journal.pone.0083737","title":"Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Structural Genomics Consortium","funders":"Biological and Environmental Research; National Research Council Canada; Canadian Institutes of Health Research; Ontario Genomics Institute; Western Economic Diversification Canada; Wellcome Trust; Ontario Genomics; Genome Canada; GlaxoSmithKline; University of Chicago; Pfizer; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Eli Lilly and Company; Argonne National Laboratory; U.S. Department of Energy","keywords":"PRC2; EZH2; Histone H3; Methyltransferase; Chemistry; Histone methyltransferase; Biology; Cell biology; Histone; Methylation; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000429874,0.00005615424,0.00009802151,0.00003101581,0.00003009177,0.000008242894,0.00004299418,0.0000589963,0.00001212469],"category_scores_gemma":[0.00008320737,0.0000444069,0.00001376698,0.0000467193,0.00007953198,0.00000646871,0.00003328405,0.00004020131,3.959252e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004845296,"about_ca_system_score_gemma":0.00002468619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002257573,"about_ca_topic_score_gemma":0.00007753752,"domain_scores_codex":[0.9995538,0.00002526627,0.0001822561,0.00008315696,0.00008782012,0.00006767439],"domain_scores_gemma":[0.9996858,0.00004042787,0.0001104137,0.00007254582,0.00006560385,0.00002518261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005067564,0.00003342517,0.09653932,0.00005061412,0.00002800127,3.255168e-8,0.0001767048,0.00002257558,0.9030405,0.00007314039,0.00000120827,0.00002941016],"study_design_scores_gemma":[0.0002116573,0.00004287917,0.2296932,0.00002386539,0.00001560695,3.610905e-7,0.00008694099,0.0001629809,0.769037,0.0006841639,9.897467e-7,0.00004036455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994067,0.0001666947,0.00003531293,0.00003436085,0.00000587289,0.0001859957,0.0001274352,9.777119e-7,0.00003666966],"genre_scores_gemma":[0.9991387,0.00005665933,0.0006790322,0.000007321908,0.0000111983,0.000004230921,0.00008404692,0.000004012789,0.0000148265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1340035,"threshold_uncertainty_score":0.1810861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02116614842341164,"score_gpt":0.2236881241154174,"score_spread":0.2025219756920058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}