{"id":"W1986945525","doi":"10.1039/c2ob26105g","title":"Synthesis and evaluation of inhibitors of E. coli PgaB, a polysaccharide de-N-acetylase involved in biofilm formation","year":2012,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Biofilm; Amide; Acetylation; Glucosamine; Polysaccharide; Escherichia coli; N-Acetylglucosamine; Bacteria; In vitro; Chelation; Biochemistry; Glycoconjugate; Stereochemistry; Enzyme; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002919173,0.0007792276,0.0004572791,0.0002971525,0.0002045116,0.0002810733,0.0005087638,0.0004250904,0.0005352533],"category_scores_gemma":[0.0002610798,0.0002651784,0.0002869353,0.000267727,0.0001632278,0.0002141737,0.0001840025,0.0005218732,0.0003159215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003970218,"about_ca_system_score_gemma":0.0003653017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00103651,"about_ca_topic_score_gemma":0.001814983,"domain_scores_codex":[0.9997777,0.00004499367,0.00002465511,0.00004244093,0.00007756829,0.00003257925],"domain_scores_gemma":[0.9998369,0.00002862674,0.00004048904,0.00001528355,0.00004403263,0.00003467418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001302811,0.0001643294,0.00006539015,0.00009730661,0.00001480165,0.00003410539,0.00001269122,0.0004962482,0.9954638,0.00008196398,0.00007376762,0.003365295],"study_design_scores_gemma":[0.00005484783,0.001190632,0.0004965863,0.000008000501,0.00003480865,0.0001145816,0.000006728249,0.0009544645,0.9937932,0.00001594205,0.003323865,0.000006233364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611713,0.01341744,0.01811547,0.0002561336,0.0001014592,0.0007165093,0.001331134,0.0002538018,0.004636807],"genre_scores_gemma":[0.9681528,0.009024012,0.01676584,0.0001014206,0.00003237763,0.0003117641,0.001760988,0.00005186424,0.003798973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103651,"threshold_uncertainty_score":0.002880633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200843767905577,"score_gpt":0.2397112221595804,"score_spread":0.2277027844805247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}