{"id":"W1986960660","doi":"10.1038/cddis.2013.348","title":"Dexamethasone shifts bone marrow stromal cells from osteoblasts to adipocytes by C/EBPalpha promoter methylation","year":2013,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":179,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"Science and Technology Commission of Shanghai Municipality; Chinese Academy of Sciences; Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"Ccaat-enhancer-binding proteins; Osteoblast; Adipocyte; DNA methylation; Endocrinology; Stromal cell; Internal medicine; Wnt signaling pathway; Chemistry; Bone marrow; Adipogenesis; Methylation; Cancer research; Biology; Cell biology; Adipose tissue; Medicine; Signal transduction; Transcription factor; Gene expression; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005704121,0.0002487184,0.0001941246,0.00004286079,0.00008499543,0.00009971546,0.0001194761,0.0001035674,0.0002766651],"category_scores_gemma":[0.00008642295,0.0002284745,0.00009156307,0.0000612755,0.0000470393,0.00001943834,0.0001259512,0.000055017,0.0001325052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005989368,"about_ca_system_score_gemma":0.00007291046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001589292,"about_ca_topic_score_gemma":0.000006955171,"domain_scores_codex":[0.9986701,0.00008130623,0.000200019,0.0005573513,0.0001546071,0.0003366421],"domain_scores_gemma":[0.998253,0.00002259567,0.00006019489,0.0003726653,0.00006074105,0.001230779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002666028,0.0002083723,0.007956331,0.00003667257,0.00002299574,0.000008079372,0.00004033274,0.000007057237,0.9673514,0.000007975381,0.01916183,0.004932322],"study_design_scores_gemma":[0.002590473,0.0003765386,0.1463964,0.00002995701,0.0002827455,9.895144e-7,0.00009444614,0.000200864,0.8232256,0.001131795,0.02477501,0.0008951965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985158,0.01247279,0.0007081517,0.0001843081,0.000113251,0.0004736299,0.0005015605,0.00002371155,0.000364642],"genre_scores_gemma":[0.9955708,0.0001367619,0.001257965,0.0009122437,0.0002170091,0.0001005415,0.0007059255,0.00003162651,0.001067154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1441259,"threshold_uncertainty_score":0.9316921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005586156735366487,"score_gpt":0.206196500584961,"score_spread":0.2006103438495945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}