{"id":"W1986960660","doi":"10.1038/cddis.2013.348","title":"Dexamethasone shifts bone marrow stromal cells from osteoblasts to adipocytes by C/EBPalpha promoter methylation","year":2013,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":179,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"Science and Technology Commission of Shanghai Municipality; Chinese Academy of Sciences; Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"Ccaat-enhancer-binding proteins; Osteoblast; Adipocyte; DNA methylation; Endocrinology; Stromal cell; Internal medicine; Wnt signaling pathway; Chemistry; Bone marrow; Adipogenesis; Methylation; Cancer research; Biology; Cell biology; Adipose tissue; Medicine; Signal transduction; Transcription factor; Gene expression; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001142802,0.0003116035,0.0002118163,0.0002682237,0.0001580197,0.000299391,0.0001991546,0.0002137875,0.00139631],"category_scores_gemma":[0.00009144515,0.0001966503,0.0003261011,0.0002061449,0.0002572845,0.0001438948,0.0002193638,0.0006686947,0.0003774569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000250935,"about_ca_system_score_gemma":0.0002720545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00101232,"about_ca_topic_score_gemma":0.002198168,"domain_scores_codex":[0.9998318,0.00001806249,0.00001835417,0.00004799404,0.00005285219,0.00003094664],"domain_scores_gemma":[0.9999441,0.0000107854,0.00001558036,0.000009091521,0.000008851914,0.00001159525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004693996,0.00001065498,0.0001250299,0.00002737887,0.000002700188,0.00002485371,0.00001189157,0.00002255572,0.9983956,0.00005787165,0.0000200153,0.001254443],"study_design_scores_gemma":[0.00001814651,0.00008907342,0.002619819,0.000005542138,0.00001536674,0.0001121543,0.0000316568,0.0003068384,0.9936898,0.00003890962,0.003068555,0.000004076428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735851,0.008297282,0.01130116,0.0003264276,0.0001267043,0.0001295011,0.001307407,0.0003019005,0.004624453],"genre_scores_gemma":[0.9807659,0.004380698,0.006905335,0.0002139058,0.00002398657,0.0001277589,0.001183347,0.0000500885,0.006349086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00139631,"threshold_uncertainty_score":0.004671097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005586156735366487,"score_gpt":0.206196500584961,"score_spread":0.2006103438495945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}