{"id":"W1986965660","doi":"10.1111/j.1538-7836.2007.02410.x","title":"Gene therapy, bioengineered clotting factors and novel technologies for hemophilia treatment","year":2007,"lang":"en","type":"review","venue":"Journal of Thrombosis and Haemostasis","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Genetic enhancement; Clotting factor; Medicine; Clinical trial; Factor IX; Ex vivo; Viral vector; Gene delivery; Gene transfer; Immunology; Immune system; Vector (molecular biology); In vivo; Intensive care medicine; Bioinformatics; Pharmacology; Gene; Biology; Internal medicine; Recombinant DNA; Biotechnology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008800225,0.001183432,0.001681969,0.0021876,0.0003389437,0.001207782,0.00137113,0.002100234,0.00272157],"category_scores_gemma":[0.0007669459,0.0003828906,0.000479721,0.00216512,0.0008553019,0.001663207,0.0005313415,0.002644593,0.002392265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000860007,"about_ca_system_score_gemma":0.0008705085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008961709,"about_ca_topic_score_gemma":0.001667954,"domain_scores_codex":[0.9997557,0.00003149055,0.00002550764,0.00003532369,0.0001297426,0.00002224234],"domain_scores_gemma":[0.9997327,0.0001355908,0.00002887955,0.00001007678,0.00006959199,0.00002315194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001597995,0.0001671031,0.0001235216,0.00767557,0.00009390047,0.0003554556,0.00005830729,0.0006095324,0.006885651,0.01039392,0.05494283,0.9185344],"study_design_scores_gemma":[0.00005007618,0.00008669477,0.0002591401,0.0008581792,0.00006314316,0.001157045,0.0000293089,0.0001361548,0.001462355,0.002304635,0.9935749,0.00001839401],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000122734,0.997583,0.0004351183,0.0002694656,0.0005457731,0.000006753701,0.00001204432,0.000009635301,0.001015409],"genre_scores_gemma":[0.0006553687,0.9969404,0.0006305776,0.0002776646,0.0002978625,0.00001194373,0.00002956577,0.000002360251,0.001154342],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00272157,"threshold_uncertainty_score":0.009104609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1865055117328377,"score_gpt":0.4142363735122303,"score_spread":0.2277308617793926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}