{"id":"W1986974478","doi":"10.1016/j.bmcl.2009.02.043","title":"Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor: Structure–activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Benzimidazole; Stereochemistry; Structure–activity relationship; Chemical synthesis; Receptor; Biological activity; Gonadotropin-releasing hormone; Gonadotropin-releasing hormone receptor; Hormone receptor; In vitro; Hormone; Small molecule; Molecule; Combinatorial chemistry; Endocrinology; Internal medicine; Biochemistry; Luteinizing hormone; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632029,0.0002478872,0.0003101329,0.0001333073,0.0001013027,0.0001622694,0.0004816043,0.0002407932,0.001532923],"category_scores_gemma":[0.0001299074,0.000167793,0.0001780679,0.000105145,0.0001493571,0.0001416363,0.0001287797,0.000391026,0.0004302455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002187523,"about_ca_system_score_gemma":0.0001527879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005712501,"about_ca_topic_score_gemma":0.002446883,"domain_scores_codex":[0.9999272,0.00001421759,0.000004336163,0.00001317084,0.0000183285,0.00002281153],"domain_scores_gemma":[0.9999574,0.0000105357,0.00001238773,0.000003568013,0.000003501693,0.0000126475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002995704,0.00009919312,0.00007932194,0.00006611367,0.00001145866,0.0000939396,0.00002313758,0.0006402197,0.9941133,0.0002810612,0.0001426081,0.004150115],"study_design_scores_gemma":[0.000433575,0.007207137,0.003445868,0.00001239166,0.0000698152,0.0005485325,0.00002794927,0.004097724,0.9762572,0.0001224941,0.007743039,0.00003425204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826124,0.005710156,0.006140243,0.0002044447,0.000105621,0.0001473546,0.0002754275,0.0001719636,0.004632453],"genre_scores_gemma":[0.9896828,0.003146898,0.00334142,0.0001055211,0.00003197537,0.00006858986,0.0003533036,0.00001144325,0.00325802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001532923,"threshold_uncertainty_score":0.005128086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02293649914731572,"score_gpt":0.227075694028195,"score_spread":0.2041391948808793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}