{"id":"W1987005520","doi":"10.1101/gad.1799609","title":"Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains","year":2009,"lang":"en","type":"article","venue":"Genes & Development","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"PTEN; Biology; PI3K/AKT/mTOR pathway; Protein kinase B; Cell biology; Signal transduction; Phosphorylation; Cancer research","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017437,0.0005958856,0.0003695777,0.001523171,0.0002341066,0.0003440308,0.0003333703,0.0003514011,0.00151102],"category_scores_gemma":[0.000214588,0.0003102855,0.0003105998,0.0002811824,0.0007038946,0.0002670804,0.0004673447,0.0006208189,0.0003105406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004490476,"about_ca_system_score_gemma":0.0003630283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007404506,"about_ca_topic_score_gemma":0.001345492,"domain_scores_codex":[0.9997725,0.00001961653,0.00002990409,0.00006189,0.00007004233,0.00004603904],"domain_scores_gemma":[0.9997802,0.00003472649,0.00007310676,0.00001953847,0.00001652866,0.00007584725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002952952,0.00002657812,0.0009768708,0.00002886508,0.00001198548,0.0005570723,0.00002867543,0.000126075,0.9958422,0.0003519664,0.00005163966,0.001702861],"study_design_scores_gemma":[0.00006470243,0.0002632544,0.0448291,0.00001439313,0.00005632918,0.005666628,0.00009255582,0.001323545,0.9457487,0.0005445013,0.001376319,0.00001981618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957954,0.0006365256,0.001239584,0.00006526798,0.000009419206,0.0000253673,0.0005954842,0.0001218805,0.001511188],"genre_scores_gemma":[0.9952331,0.0004878297,0.001762797,0.00005283606,0.000004858569,0.00006167308,0.0006626726,0.00006062342,0.00167351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001523171,"threshold_uncertainty_score":0.005054832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01344484096136501,"score_gpt":0.2414475668918885,"score_spread":0.2280027259305235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}