{"id":"W1987105457","doi":"10.1038/ni1465","title":"The NEMO adaptor bridges the nuclear factor-κB and interferon regulatory factor signaling pathways","year":2007,"lang":"en","type":"article","venue":"Nature Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":318,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute; McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"IRF3; Interferon regulatory factors; Signal transducing adaptor protein; IRF7; Cell biology; IκB kinase; Phosphorylation; Transcription factor; RNA Helicase A; Ectopic expression; TANK-binding kinase 1; Signal transduction; TRIF; Biology; Ultrabithorax; NF-κB; RNA; Helicase; Gene; Protein kinase A; Biochemistry; Innate immune system; Toll-like receptor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003796497,0.0002848906,0.0003634242,0.0002389057,0.0006709839,0.001051443,0.0005904965,0.0007090049,0.00306821],"category_scores_gemma":[0.0005417033,0.0002278911,0.0002144487,0.0001757754,0.0005672621,0.001576054,0.001700747,0.001047176,0.001566529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004447908,"about_ca_system_score_gemma":0.0003840701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001946191,"about_ca_topic_score_gemma":0.000311668,"domain_scores_codex":[0.9997764,0.00002800301,0.00001183684,0.0000359062,0.00007233661,0.0000755032],"domain_scores_gemma":[0.9997795,0.00002962574,0.00005284453,0.0000377032,0.00002960908,0.00007080396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009732451,0.00006087413,0.001651676,0.0001767951,0.00002223261,0.0006783993,0.0001237551,0.0005264779,0.9535254,0.0157272,0.001279556,0.02525435],"study_design_scores_gemma":[0.0001559689,0.0002536497,0.02557359,0.000134499,0.00006652871,0.003399102,0.000619291,0.008953146,0.8588732,0.02075033,0.08114696,0.00007377187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9365121,0.01392575,0.02195401,0.002905897,0.0007480868,0.00003381405,0.0003394156,0.000449143,0.02313183],"genre_scores_gemma":[0.9860784,0.002887514,0.002706156,0.0003175864,0.0001229199,0.00001879868,0.0003085425,0.00004589811,0.007514214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00306821,"threshold_uncertainty_score":0.01026416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009637071630447979,"score_gpt":0.232503482565258,"score_spread":0.22286641093481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}