{"id":"W1987128219","doi":"10.1016/s1367-5931(02)00011-x","title":"Functional genomics of intracellular peptide recognition domains with combinatorial biology methods","year":2003,"lang":"en","type":"review","venue":"Current Opinion in Chemical Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"","keywords":"PDZ domain; Computational biology; Phage display; Biology; Peptide library; Peptide; Genomics; Protein–protein interaction; Functional genomics; Structural genomics; Peptide sequence; Gene; Biochemistry; Protein structure; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001053302,0.001234993,0.001817042,0.0009682038,0.0002206556,0.0012638,0.001845548,0.0008935257,0.001581882],"category_scores_gemma":[0.0004909809,0.0004137979,0.0007080616,0.001073797,0.00122403,0.001105867,0.0007186523,0.002056801,0.00129928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009870093,"about_ca_system_score_gemma":0.0004240903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003668517,"about_ca_topic_score_gemma":0.0004764062,"domain_scores_codex":[0.9996021,0.00006196378,0.00002685588,0.0001075483,0.0001519093,0.00004966169],"domain_scores_gemma":[0.999734,0.0001361313,0.000031864,0.00003083292,0.00004595292,0.00002120893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002011522,0.0001858043,0.0002196834,0.00399498,0.0000814488,0.0003228513,0.00006267233,0.00432058,0.3148341,0.0358225,0.006589511,0.6333647],"study_design_scores_gemma":[0.0001910721,0.0004878748,0.001939082,0.0006638651,0.0002503792,0.002875795,0.00008798673,0.008318424,0.4574525,0.03212279,0.4954572,0.0001530427],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02147972,0.7727531,0.1865992,0.001893539,0.001597288,0.0001402224,0.0003162412,0.0007483691,0.01447229],"genre_scores_gemma":[0.09603126,0.7276226,0.1617851,0.00182336,0.0009673649,0.0003638485,0.001312035,0.000160444,0.009933889],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001845548,"threshold_uncertainty_score":0.00716126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1064339643481973,"score_gpt":0.3874014085330608,"score_spread":0.2809674441848635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}