{"id":"W1987128219","doi":"10.1016/s1367-5931(02)00011-x","title":"Functional genomics of intracellular peptide recognition domains with combinatorial biology methods","year":2003,"lang":"en","type":"review","venue":"Current Opinion in Chemical Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"","keywords":"PDZ domain; Computational biology; Phage display; Biology; Peptide library; Peptide; Genomics; Protein–protein interaction; Functional genomics; Structural genomics; Peptide sequence; Gene; Biochemistry; Protein structure; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006316506,0.0004920849,0.001240281,0.0001682866,0.00003433198,0.000007611031,0.0003136287,0.001142529,0.00008114782],"category_scores_gemma":[0.0002169553,0.0004056751,0.0003428309,0.0002375271,0.0004040796,0.00000305555,0.0001789437,0.0006232781,0.0000186489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008822993,"about_ca_system_score_gemma":0.0004171398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002763149,"about_ca_topic_score_gemma":3.354502e-7,"domain_scores_codex":[0.9969073,0.0008730893,0.0008885625,0.0008319564,0.00007306081,0.0004260415],"domain_scores_gemma":[0.9986171,0.0001783796,0.0005603784,0.0004057796,0.0001243224,0.0001140017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001596522,0.0003177652,0.00004948681,0.004444019,0.0001849655,3.321804e-7,0.0000102664,3.314828e-7,0.03876754,0.002363681,0.0005124414,0.9531896],"study_design_scores_gemma":[0.0008995216,0.0003800781,4.704559e-7,0.001132695,0.00008420975,0.00004527581,0.000004366862,0.000001033299,0.02476745,0.002655753,0.9695638,0.000465384],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006941591,0.9893115,0.004167843,0.000007295084,0.004484535,0.0007226564,0.0003732378,0.00001297141,0.0002257751],"genre_scores_gemma":[0.00007761358,0.9815919,0.005212941,0.000009754414,0.001187166,0.0002730251,0.0115899,0.00005058415,0.000007053867],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9690513,"threshold_uncertainty_score":0.9998395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1064339643481973,"score_gpt":0.3874014085330608,"score_spread":0.2809674441848635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}