{"id":"W1987155536","doi":"10.1016/j.pain.2013.03.021","title":"mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK","year":2013,"lang":"en","type":"article","venue":"Pain","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research","keywords":"mTORC1; MAPK/ERK pathway; PI3K/AKT/mTOR pathway; Sensitization; Activator (genetics); Medicine; Metformin; Kinase; Pharmacology; Sensory system; Signal transduction; Neuroscience; Receptor; Endocrinology; Internal medicine; Biology; Insulin; Cell biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001113959,0.00008628616,0.00007461941,0.00004779349,0.00004319723,0.0000137362,0.00004059471,0.0001352917,0.0001859089],"category_scores_gemma":[0.0003046558,0.00008199212,0.00004635645,0.00007207424,0.00002653227,0.0000097626,0.00002226439,0.00004487284,0.00003139163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001912868,"about_ca_system_score_gemma":0.0000189784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005709233,"about_ca_topic_score_gemma":0.000005012024,"domain_scores_codex":[0.9990773,0.0003477864,0.0001737017,0.0001679094,0.000124484,0.0001088167],"domain_scores_gemma":[0.9995653,0.0000396022,0.0001033882,0.0001336796,0.0001187791,0.00003924605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002174042,0.00004599622,0.0003954894,0.00001848864,0.00001297517,7.690895e-8,0.00005596708,0.0001734136,0.9574576,0.00005713928,0.005810504,0.03595061],"study_design_scores_gemma":[0.0003626591,0.0002138843,0.003015625,0.0000241376,0.000004581385,0.000001262585,0.0002589273,0.003964568,0.9853702,0.0005438291,0.006088755,0.0001516114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7635128,0.00003232994,0.2348428,0.0004503706,0.0001492678,0.0002233435,0.000002529265,0.00001595653,0.0007705731],"genre_scores_gemma":[0.9980424,0.00001130712,0.0001918528,0.0004424473,0.0003248788,0.00003539322,0.0002158349,0.00001143797,0.0007244536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2346509,"threshold_uncertainty_score":0.3343542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053775255449644,"score_gpt":0.2155493548238224,"score_spread":0.205011602269326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}