{"id":"W1987175610","doi":"10.1074/jbc.m109.018838","title":"Kaposi Sarcoma-associated Herpesvirus Latency-associated Nuclear Antigen Inhibits Interferon (IFN) β Expression by Competing with IFN Regulatory Factor-3 for Binding to IFNB Promoter","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Primary effusion lymphoma; Biology; Kaposi's sarcoma-associated herpesvirus; Interferon regulatory factors; IRF4; Virology; Transcription factor; Lytic cycle; IRF3; Interferon; Nuclear protein; Virus latency; Promoter; Molecular biology; Gene expression; Viral replication; Gene; Virus; Genetics; Herpesviridae","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001482401,0.0003393775,0.0002311189,0.0001235695,0.0001166107,0.0002183105,0.0001926519,0.0001634116,0.001159547],"category_scores_gemma":[0.0001136152,0.0001225851,0.0003048951,0.00007527943,0.0001774156,0.0001433091,0.0001608219,0.0005589877,0.0003827706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002328766,"about_ca_system_score_gemma":0.0002096097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002990687,"about_ca_topic_score_gemma":0.0004199476,"domain_scores_codex":[0.9998393,0.00003373519,0.00001353112,0.00002792077,0.00004688565,0.00003857606],"domain_scores_gemma":[0.999916,0.0000202668,0.00002365814,0.00001252624,0.000009051048,0.00001863024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000568222,0.00002042634,0.00007635835,0.00002376932,0.00000317839,0.000008022019,0.000005126895,0.00002511206,0.9989638,0.00005766673,0.000009866019,0.0007497853],"study_design_scores_gemma":[0.00001277581,0.0002283151,0.001274698,0.000006096915,0.000007843255,0.000139526,0.000008353602,0.000413136,0.9960434,0.00003974031,0.001823938,0.000002055047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869958,0.004361221,0.005288444,0.00008008254,0.00004503286,0.00003624809,0.0001582264,0.00009160509,0.002943384],"genre_scores_gemma":[0.9927792,0.001368252,0.003572037,0.00004627924,0.00001435669,0.00003843422,0.0003256706,0.00002015368,0.001835664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001159547,"threshold_uncertainty_score":0.00387907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01760888901877595,"score_gpt":0.2586008426410196,"score_spread":0.2409919536222436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}