{"id":"W1987178054","doi":"10.1371/journal.pone.0004020","title":"Phosphorylation Regulates SIRT1 Function","year":2008,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":289,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute on Aging; Harvard University; Fondation pour la Recherche Médicale; York University; University of Virginia; National Cancer Institute; National Institutes of Health","keywords":"Biology; NAD+ kinase; Phosphorylation; Cell biology; Cyclin-dependent kinase 1; Cell cycle; Dephosphorylation; Sirtuin 1; Activator (genetics); Cell growth; Phosphatase; Biochemistry; Molecular biology; Cell; Downregulation and upregulation; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008850963,0.00009247213,0.0002269183,0.00007469432,0.0001046124,0.000003490526,0.00002882624,0.00008374107,0.0005977374],"category_scores_gemma":[0.0001013106,0.00007131196,0.00004531733,0.0001592793,0.00007166465,0.00005276618,0.00001069188,0.0001541195,0.0001596608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003782371,"about_ca_system_score_gemma":0.00003748998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001404625,"about_ca_topic_score_gemma":9.182922e-7,"domain_scores_codex":[0.999093,0.00001349247,0.0001701948,0.0001657924,0.00040779,0.0001497494],"domain_scores_gemma":[0.9994715,0.00002910886,0.00004446942,0.0002208556,0.0001275178,0.0001064833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00144881,0.004201012,0.1594549,0.000310722,0.001014816,0.0001980276,0.0007060434,0.00001576571,0.8122355,0.0003748414,0.0146337,0.005405955],"study_design_scores_gemma":[0.005592254,0.002550836,0.6698462,0.0007714661,0.001177068,0.0001613095,0.0001633546,0.003883429,0.3106938,0.0003624662,0.004475339,0.0003224937],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900864,0.00118072,0.00009167909,0.00121784,0.00009827047,0.0002489411,8.365371e-7,0.0001241755,0.006951158],"genre_scores_gemma":[0.9865304,0.0004587931,0.001133731,0.0007565808,0.0006782447,0.00001334221,0.00004149469,0.00001916343,0.01036822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5103913,"threshold_uncertainty_score":0.6544806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05050080154198555,"score_gpt":0.2243100296769965,"score_spread":0.1738092281350109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}