{"id":"W1987178054","doi":"10.1371/journal.pone.0004020","title":"Phosphorylation Regulates SIRT1 Function","year":2008,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":289,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute on Aging; Harvard University; Fondation pour la Recherche Médicale; York University; University of Virginia; National Cancer Institute; National Institutes of Health","keywords":"Biology; NAD+ kinase; Phosphorylation; Cell biology; Cyclin-dependent kinase 1; Cell cycle; Dephosphorylation; Sirtuin 1; Activator (genetics); Cell growth; Phosphatase; Biochemistry; Molecular biology; Cell; Downregulation and upregulation; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054138,0.0005905083,0.0001784341,0.0001962109,0.0002477104,0.000423767,0.0002971347,0.0003473329,0.00455364],"category_scores_gemma":[0.0001484919,0.000134118,0.0002627353,0.0001660503,0.0002601465,0.0002176812,0.0002093984,0.0004520583,0.001396518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004017661,"about_ca_system_score_gemma":0.000148871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003387087,"about_ca_topic_score_gemma":0.0004469024,"domain_scores_codex":[0.9998993,0.000007941109,0.00000669989,0.0000412011,0.00001976262,0.00002514306],"domain_scores_gemma":[0.9998716,0.00001133915,0.00006350346,0.000008614249,0.00001467996,0.0000302338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003222571,0.00002935339,0.001592711,0.0001254066,0.00001324207,0.0000896627,0.00001593143,0.0001004447,0.9932702,0.0001554651,0.0002291786,0.004056091],"study_design_scores_gemma":[0.00004161714,0.0002787079,0.03270482,0.00002510858,0.00005652184,0.0008037282,0.00003522202,0.001328691,0.9569466,0.0002407695,0.007523245,0.00001493655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839566,0.007143991,0.003735404,0.0003842105,0.0001688136,0.0000324597,0.001479445,0.0001947667,0.002904265],"genre_scores_gemma":[0.9929202,0.001918898,0.001787345,0.0001149123,0.00004694527,0.00001470192,0.001421791,0.00003543351,0.001739764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00455364,"threshold_uncertainty_score":0.01523346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05050080154198555,"score_gpt":0.2243100296769965,"score_spread":0.1738092281350109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}