{"id":"W1987211426","doi":"10.1186/s12879-015-0905-0","title":"Tetrandrine reverses drug resistance in isoniazid and ethambutol dual drug-resistant Mycobacterium tuberculosis clinical isolates","year":2015,"lang":"en","type":"article","venue":"BMC Infectious Diseases","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases; Zhejiang University","keywords":"Ethambutol; Tetrandrine; Efflux; Drug resistance; Isoniazid; Mycobacterium tuberculosis; Pharmacology; Drug; Medicine; Rifampicin; Tuberculosis; Microbiology; Multiple drug resistance; Biology; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001491233,0.0002139161,0.0004458693,0.0002576318,0.0001297001,0.0002252565,0.0003461041,0.0002768631,0.0009991899],"category_scores_gemma":[0.0005336242,0.0001091206,0.0002100434,0.0001206632,0.0001157457,0.0001462658,0.0001612977,0.0003573122,0.0001851572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001059472,"about_ca_system_score_gemma":0.000117274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002763612,"about_ca_topic_score_gemma":0.0006377122,"domain_scores_codex":[0.9998376,0.00004086626,0.00002818176,0.00003202628,0.00003823851,0.00002300885],"domain_scores_gemma":[0.9997737,0.00004709795,0.00006436525,0.000040657,0.00004000812,0.00003418305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009147536,0.0005528583,0.003060252,0.0001910244,0.00004341819,0.000265488,0.00007262918,0.00008013177,0.9719472,0.00002414036,0.0001532682,0.02269483],"study_design_scores_gemma":[0.0002376877,0.01120802,0.04958095,0.00006640612,0.0002277278,0.002835622,0.000108219,0.001326915,0.9272229,0.00004937422,0.007119862,0.00001631618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970341,0.001849265,0.0003314656,0.00007176792,0.00003436946,0.00003767454,0.0000685452,0.00004002269,0.0005328045],"genre_scores_gemma":[0.9964615,0.0007053025,0.001555414,0.00005374818,0.0000243639,0.00002310415,0.0002053943,0.00001122856,0.0009600149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009991899,"threshold_uncertainty_score":0.003342569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02985372026086713,"score_gpt":0.3289050831050836,"score_spread":0.2990513628442165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}