{"id":"W1987211450","doi":"10.1016/j.molcel.2013.01.017","title":"Regulation of DNA Damage Responses by Ubiquitin and SUMO","year":2013,"lang":"en","type":"review","venue":"Molecular Cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":594,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Cancer Research UK; Wellcome Trust","keywords":"Biology; Ubiquitin; DNA damage; DNA; Cell biology; DNA repair; Ubiquitins; SUMO protein; Genetics; Computational biology; Ubiquitin ligase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006475877,0.001406808,0.001567592,0.001540415,0.0003071437,0.001280852,0.00133208,0.001328682,0.002119893],"category_scores_gemma":[0.0004647764,0.0003954591,0.0003609723,0.002116538,0.0008654308,0.001539157,0.0009862389,0.00201681,0.002033335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009156435,"about_ca_system_score_gemma":0.0008828961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007860935,"about_ca_topic_score_gemma":0.00166755,"domain_scores_codex":[0.9998102,0.00002025403,0.00002420055,0.00003955601,0.00007681469,0.00002913856],"domain_scores_gemma":[0.9998028,0.00006017055,0.00003570088,0.00001169317,0.00005923583,0.00003045291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001295522,0.00005644035,0.0001641431,0.006774506,0.00006678511,0.0002597336,0.00003614591,0.0006015483,0.007637235,0.005772309,0.03102643,0.9474752],"study_design_scores_gemma":[0.00001867778,0.00004496168,0.0006982318,0.0008354239,0.00006984645,0.0007903187,0.00004490901,0.0001356004,0.002459347,0.003619178,0.9912607,0.00002280149],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001637798,0.9973212,0.0005327741,0.0002985728,0.0003267851,0.000005007898,0.00002401573,0.00001519219,0.001312743],"genre_scores_gemma":[0.0008822054,0.9974338,0.0003491254,0.0001923321,0.0002328854,0.000007114722,0.00003850469,0.00000198911,0.0008620198],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002119893,"threshold_uncertainty_score":0.007091761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0194402798777308,"score_gpt":0.2705467474111936,"score_spread":0.2511064675334628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}