{"id":"W1987213192","doi":"10.1016/j.bmcl.2009.01.075","title":"Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Benzimidazole; Chemistry; In vitro; Antibiotics; Mechanism of action; Antibacterial agent; Pharmacology; Drug; Antibacterial activity; Stereochemistry; Combinatorial chemistry; Chemical synthesis; Bacteria; Biochemistry; Organic chemistry; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002448885,0.0002587094,0.0002708836,0.000226136,0.0001697678,0.000167726,0.0003387798,0.0002314835,0.001530819],"category_scores_gemma":[0.0002357923,0.0001381484,0.0001684907,0.0002092379,0.0001262325,0.0001420812,0.000126523,0.0003075369,0.0003809179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002309187,"about_ca_system_score_gemma":0.0002496951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00119707,"about_ca_topic_score_gemma":0.00256439,"domain_scores_codex":[0.9998581,0.0000346994,0.00001689244,0.00001781173,0.00003736268,0.00003504269],"domain_scores_gemma":[0.9999082,0.00001683394,0.00001738992,0.00001130067,0.00002071479,0.00002549018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004655168,0.0001023204,0.0001049083,0.000107622,0.00000948397,0.000122028,0.00002740935,0.0003144202,0.9918196,0.000143356,0.0002055448,0.006577758],"study_design_scores_gemma":[0.000085971,0.001998662,0.001650666,0.00001200399,0.00003208996,0.0003595003,0.00001187375,0.0005555275,0.9896789,0.00003086099,0.005573743,0.0000102835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753246,0.0146414,0.003268062,0.0002100676,0.0001166282,0.0001196621,0.0006769641,0.00007982214,0.005562677],"genre_scores_gemma":[0.9876052,0.004647217,0.003611252,0.00007847021,0.00004188308,0.0000426335,0.001091992,0.00001392679,0.00286735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001530819,"threshold_uncertainty_score":0.005121112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578551715751678,"score_gpt":0.2370311161224778,"score_spread":0.221245598964961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}