{"id":"W1987276369","doi":"10.1016/j.virusres.2013.10.014","title":"Coxsackievirus B3-induced calpain activation facilitates the progeny virus replication via a likely mechanism related with both autophagy enhancement and apoptosis inhibition in the early phase of infection: An in vitro study in H9c2 cells","year":2013,"lang":"en","type":"article","venue":"Virus Research","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Lawson Health Research Institute","funders":"Canadian Institutes of Health Research; Program of Shanghai Subject Chief Scientist; Universidad de Playa Ancha; National Natural Science Foundation of China","keywords":"Calpain; Autophagy; Apoptosis; Biology; Viral replication; Cell biology; Coxsackievirus; Programmed cell death; Virus; Virology; Biochemistry; Enterovirus; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004936867,0.0001817075,0.0003116879,0.0009127764,0.0002358244,0.00008298871,0.0001229135,0.0001731971,0.00006375779],"category_scores_gemma":[0.0002435172,0.0001137227,0.00003411734,0.002166864,0.0002468794,0.0004835513,0.00008828029,0.001167181,0.00002960546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003077893,"about_ca_system_score_gemma":0.0001646487,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0525386,"about_ca_topic_score_gemma":0.002013772,"domain_scores_codex":[0.9956911,0.002015245,0.0005985863,0.0005411025,0.0006818451,0.0004721409],"domain_scores_gemma":[0.9984674,0.0002890521,0.0001147246,0.0007245095,0.0003359668,0.000068391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001170493,0.003432648,0.002674572,0.00003878895,0.0000427063,0.000007626929,0.005687576,0.000004383042,0.9622899,0.00004057953,0.000006847736,0.02460391],"study_design_scores_gemma":[0.003634028,0.007209796,0.1186856,0.00008196691,0.00001093673,0.000008115631,0.001597686,0.001746316,0.8665678,0.0003366344,0.00001751465,0.0001035818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933512,0.00007136814,0.00009956187,0.0005553522,0.00001750988,0.005797208,0.000005199323,0.00002238731,0.00008018127],"genre_scores_gemma":[0.9971673,0.0001705725,0.000034726,0.00004554196,0.00001412569,0.002469914,0.00002388925,0.00002063198,0.00005328772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1160111,"threshold_uncertainty_score":0.9537706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0815580170348558,"score_gpt":0.3881097399529655,"score_spread":0.3065517229181097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}