{"id":"W1987293058","doi":"10.1021/bi051917j","title":"Ca<sup>2+</sup> Dependency of Calpain 3 (p94) Activation","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Chemistry; Calpain; Cleavage (geology); Intramolecular force; Enzyme; Active site; Stereochemistry; Proteolysis; Protease; Hydrolysis; Biophysics; Biochemistry; Crystallography; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257556,0.0001344844,0.0001053155,0.00002899586,0.00005494472,0.00001049192,0.00009916179,0.0002519057,0.0001172173],"category_scores_gemma":[0.00007739426,0.0001342028,0.0001010554,0.00009335789,0.00006604678,0.000003681032,0.0000431687,0.00006576981,0.000008870785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002685739,"about_ca_system_score_gemma":0.00008480292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009388597,"about_ca_topic_score_gemma":0.000002798884,"domain_scores_codex":[0.9991357,0.00002888546,0.000236502,0.000281319,0.0001636373,0.0001539545],"domain_scores_gemma":[0.9994261,0.00000870629,0.000108405,0.000302529,0.0001047983,0.00004950826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006687501,0.00008334011,0.001063537,0.00005255141,0.00001732639,6.560191e-7,0.000009065565,0.0009120855,0.9871339,0.00003605348,0.009674313,0.0009502928],"study_design_scores_gemma":[0.0004147307,0.00004246529,0.0008061142,0.00001974156,0.00001076755,0.000009304031,0.00006837692,0.0011074,0.988113,0.0001222424,0.009126321,0.000159471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912901,0.0002170447,0.004685373,0.0001315911,0.00004409051,0.0001273117,0.00002173911,0.00002030274,0.003462456],"genre_scores_gemma":[0.9932285,0.000009588523,0.0003979205,0.00007378437,0.0004785009,0.00001869624,0.0006550368,0.00001646497,0.005121505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004287452,"threshold_uncertainty_score":0.5472631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004116135275851716,"score_gpt":0.2054667232911586,"score_spread":0.2013505880153069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}