{"id":"W1987293058","doi":"10.1021/bi051917j","title":"Ca<sup>2+</sup> Dependency of Calpain 3 (p94) Activation","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Chemistry; Calpain; Cleavage (geology); Intramolecular force; Enzyme; Active site; Stereochemistry; Proteolysis; Protease; Hydrolysis; Biophysics; Biochemistry; Crystallography; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001840041,0.0003795142,0.0005028488,0.000194739,0.0002419441,0.0006492717,0.0005388822,0.0004362067,0.003301261],"category_scores_gemma":[0.0004602227,0.0001648669,0.0004869412,0.0003105536,0.0003421137,0.0004219247,0.0003627811,0.0007546383,0.0009839733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005985119,"about_ca_system_score_gemma":0.0003382947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001800169,"about_ca_topic_score_gemma":0.00189998,"domain_scores_codex":[0.9995077,0.00003909889,0.00006473899,0.00008809088,0.0001394159,0.0001610672],"domain_scores_gemma":[0.9995709,0.00009162872,0.0001041789,0.00005815805,0.0001048589,0.00007034226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001134045,0.00006396115,0.0006412319,0.0002060735,0.00002134943,0.0003231694,0.00004422161,0.0000843435,0.9928707,0.0002332199,0.0005149719,0.00386282],"study_design_scores_gemma":[0.00005621731,0.0001747811,0.01900838,0.00001495059,0.00002250766,0.0006289484,0.00004162587,0.0007251236,0.9736335,0.0001834748,0.005500494,0.00001001726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9575009,0.02300297,0.005583144,0.001107215,0.0003167456,0.000115072,0.003216197,0.0004716635,0.008686147],"genre_scores_gemma":[0.9909256,0.002532651,0.001867732,0.0003159448,0.0000555492,0.00009292855,0.00162628,0.00005653936,0.002526882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003301261,"threshold_uncertainty_score":0.01104385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004116135275851716,"score_gpt":0.2054667232911586,"score_spread":0.2013505880153069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}