{"id":"W1987293889","doi":"10.1021/ed200417d","title":"Synthesizing Novel Anthraquinone Natural Product-like Compounds To Investigate Protein–Ligand Interactions in Both an in Vitro and in Vivo Assay: An Integrated Research-Based Third-Year Chemical Biology Laboratory Course","year":2012,"lang":"en","type":"article","venue":"Journal of Chemical Education","topic":"Various Chemistry Research Topics","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Chemical biology; Natural product; Class (philosophy); Chemistry; Modular design; Curriculum; Syllabus; Mathematics education; Computational biology; Biochemical engineering; Biology; Computer science; Biochemistry; Engineering; Mathematics; Psychology; Pedagogy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002000087,0.0002283545,0.0004111318,0.0004035452,0.00004363307,0.00008860111,0.0003917156,0.0002045613,0.00003103919],"category_scores_gemma":[0.002725338,0.0002183805,0.00003876484,0.0007625844,0.0003870761,0.0006584508,0.00008218049,0.002239665,0.000001532031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000949001,"about_ca_system_score_gemma":0.0017219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002032741,"about_ca_topic_score_gemma":0.00005681363,"domain_scores_codex":[0.9976604,0.0002191292,0.0007095718,0.0003699088,0.0004193466,0.0006216315],"domain_scores_gemma":[0.9981015,0.0002620652,0.0002307517,0.0003393319,0.0005077061,0.0005586811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006011419,0.001938008,0.01206086,0.0001252755,0.00001318564,0.000005020485,0.0007199599,0.000004351275,0.9835292,0.00001984454,0.0001867132,0.0007964804],"study_design_scores_gemma":[0.0008181397,0.00003210836,0.0006881679,0.0004800618,0.000008213694,0.00004847931,0.001014526,0.0004988094,0.9952646,0.000115508,0.000815576,0.000215838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971043,0.0002439802,0.000006878303,0.002139528,0.0001324784,0.0002082926,0.00001970954,0.00001651334,0.0001283317],"genre_scores_gemma":[0.9937943,0.000005364709,0.005401216,0.0001043004,0.0005251892,0.00005550661,0.00004505601,0.00003280078,0.00003623371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01173541,"threshold_uncertainty_score":0.9730355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04083002289884722,"score_gpt":0.3723167663372621,"score_spread":0.3314867434384148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}