{"id":"W1987328650","doi":"10.1016/j.bmcl.2011.07.091","title":"Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chemistry; Substituent; Steric effects; Pyrimidine; Amine gas treating; Stereochemistry; IC50; Butyrylcholinesterase; Potency; Cholinesterase; Ring (chemistry); Aché; Acetylcholinesterase; Enzyme; In vitro; Pharmacology; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003121673,0.0005242177,0.0004367105,0.0002109142,0.0001736946,0.0001998177,0.0006510951,0.0003903258,0.001480363],"category_scores_gemma":[0.0001693596,0.0002412813,0.0002104919,0.0001160284,0.0001346482,0.0003376376,0.0002064754,0.0004065725,0.0006270105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003263257,"about_ca_system_score_gemma":0.0002436801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005677536,"about_ca_topic_score_gemma":0.001240125,"domain_scores_codex":[0.9999,0.00002204051,0.00000773882,0.00002078094,0.00002089625,0.0000285877],"domain_scores_gemma":[0.9999429,0.000007925197,0.00001470699,0.000005360631,0.00001301071,0.00001616951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006360096,0.0001681032,0.000110707,0.000216003,0.00002290423,0.0002176401,0.00005473289,0.0005566466,0.9782025,0.0005146809,0.0002992737,0.01900087],"study_design_scores_gemma":[0.0002857232,0.002832823,0.0009452627,0.00001562277,0.00005689136,0.0006379961,0.00001572637,0.001952662,0.9813499,0.00006761844,0.01181897,0.0000208333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9448574,0.02150705,0.02037126,0.0002931714,0.0002264728,0.0003803468,0.0005432007,0.0004467297,0.01137437],"genre_scores_gemma":[0.9751902,0.007141447,0.01006898,0.000106036,0.0000466715,0.0001938783,0.0005214751,0.0000359353,0.006695378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001480363,"threshold_uncertainty_score":0.004952312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06770903664879738,"score_gpt":0.2826802974933259,"score_spread":0.2149712608445285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}