{"id":"W1987352316","doi":"10.1074/jbc.m109.084616","title":"Mammalian Numb-interacting Protein 1/Dual Oxidase Maturation Factor 1 Directs Neuronal Fate in Stem Cells","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Ottawa; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"P19 cell; Cell biology; Biology; Embryonal carcinoma; Stem cell; Embryonic stem cell; Cellular differentiation; Ectopic expression; Retinoic acid; Transcription factor; NUMB; Adult stem cell; Cell culture; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001432731,0.0001451672,0.0001670428,0.00002020886,0.00003753119,0.00003625515,0.0001359557,0.0002963767,0.0001576193],"category_scores_gemma":[0.0001037368,0.0001055969,0.0001144358,0.00005269703,0.00004544458,0.00001118359,0.00005315172,0.0005484566,0.000004457951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001472036,"about_ca_system_score_gemma":0.00003446171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002077154,"about_ca_topic_score_gemma":0.000002897227,"domain_scores_codex":[0.9991292,0.00004214621,0.0003443976,0.0001983357,0.0001031,0.0001827629],"domain_scores_gemma":[0.9993826,0.00001801513,0.000292189,0.0001249047,0.00008424201,0.00009811505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002961824,0.00004687984,0.001437577,0.00001569463,0.00001161644,0.00002501827,0.0000127707,0.000005346486,0.9956139,0.000002035251,0.0001254659,0.002407478],"study_design_scores_gemma":[0.0003619971,0.0001678226,0.006988772,0.00001771958,0.000004134403,0.0001634483,0.00004695521,0.00001225683,0.9857654,0.00001900654,0.006326616,0.0001258807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990619,0.00003091716,0.00003353737,0.0001038374,0.0003793843,0.00006843376,0.00001029495,0.000006084012,0.0003056386],"genre_scores_gemma":[0.9984161,0.000009984696,0.000458178,0.00005530469,0.0007809587,0.000001415604,0.00001394744,0.00001074516,0.000253329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009848545,"threshold_uncertainty_score":0.4306115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01206637532956192,"score_gpt":0.2304563905324285,"score_spread":0.2183900152028665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}