{"id":"W1987363328","doi":"10.1523/jneurosci.5269-14.2015","title":"Optogenetic Evidence for Inhibitory Signaling from Orexin to MCH Neurons via Local Microcircuits","year":2015,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Royal Society; Francis Crick Institute","keywords":"Optogenetics; Orexin; Dynorphin; Neuroscience; Inhibitory postsynaptic potential; Lateral hypothalamus; Narcolepsy; Wakefulness; GABAergic; Melanin-concentrating hormone; Glutamate receptor; Chemistry; Neuropeptide; Receptor; Hypothalamus; Biology; Opioid peptide; Opioid; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009191077,0.0002571082,0.0001353719,0.0001108169,0.0001360733,0.0002113823,0.0003093816,0.0001905386,0.0005936917],"category_scores_gemma":[0.0001332376,0.0001320868,0.000194551,0.00004801808,0.0002431735,0.0001987874,0.0002631788,0.0004375087,0.00009458872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000357253,"about_ca_system_score_gemma":0.0002063713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008699695,"about_ca_topic_score_gemma":0.00151335,"domain_scores_codex":[0.9999142,0.000008188616,0.000006396078,0.00002133452,0.00002326328,0.00002662279],"domain_scores_gemma":[0.9998994,0.0000285685,0.00002874644,0.00001011232,0.00001044008,0.00002272609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003120281,0.000005417583,0.0001056159,0.00001482981,0.000002039325,0.00002282946,0.000006699738,0.00004908928,0.9988806,0.0002070034,0.00001351745,0.0006612244],"study_design_scores_gemma":[0.00002233769,0.0001769801,0.006844429,0.000005391912,0.00002762106,0.00008974537,0.00002110475,0.002794811,0.9889417,0.0001249133,0.0009472134,0.0000038822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879293,0.0005826084,0.009350078,0.0001633907,0.0000392452,0.000028666,0.0001383007,0.00009865423,0.001669773],"genre_scores_gemma":[0.9944777,0.0004077284,0.003830876,0.00006191066,0.00001239629,0.00004358594,0.00008329275,0.00001875758,0.001063652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008699695,"threshold_uncertainty_score":0.002592087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2676057657588645,"score_gpt":0.3910895106749221,"score_spread":0.1234837449160576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}