{"id":"W1987393720","doi":"10.1021/bi001240u","title":"Energetics of the Induced Structural Change in a Ca<sup>2+</sup> Regulatory Protein:  Ca<sup>2+</sup> and Troponin I Peptide Binding to the E41A Mutant of the N-Domain of Skeletal Troponin C","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Peptide; Conformational change; Biophysics; Binding site; Troponin C; Mutant; Binding domain; Dissociation constant; Troponin I; Stereochemistry; Crystallography; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004452899,0.0003599807,0.000404941,0.00004586321,0.0001440935,0.00001734054,0.0008119949,0.000375598,0.00009473041],"category_scores_gemma":[0.0001558355,0.0002225002,0.0002474931,0.0003116087,0.0003409294,0.00000848455,0.0003170646,0.0002359663,0.000001565428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005204933,"about_ca_system_score_gemma":0.0001861932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000223238,"about_ca_topic_score_gemma":0.0000174243,"domain_scores_codex":[0.9977938,0.0002535052,0.000607547,0.0004977909,0.0004260925,0.0004212426],"domain_scores_gemma":[0.9984069,0.00002867804,0.0002979941,0.001080496,0.00008443135,0.0001014732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000154702,0.00004508739,0.0004017831,0.0001281732,0.00005997778,0.000002136354,0.001382262,0.0003135302,0.9961495,0.00004451671,0.00008346136,0.001234806],"study_design_scores_gemma":[0.0005909595,0.0001705631,0.0008212581,0.0002248362,0.00003577599,0.00003355071,0.001093885,0.0004986764,0.9954427,0.00006979474,0.0007573317,0.0002607067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975233,0.0005867477,0.000006445636,0.0006468558,0.00003842112,0.0008634827,0.0001825279,0.000005626182,0.0001466141],"genre_scores_gemma":[0.9986016,0.00003561378,0.0003497681,0.0001329551,0.0002090488,0.0001187048,0.0000216545,0.00004207075,0.0004885608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001078344,"threshold_uncertainty_score":0.9073296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008583338336847077,"score_gpt":0.2214614887865045,"score_spread":0.2128781504496574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}