{"id":"W1987393720","doi":"10.1021/bi001240u","title":"Energetics of the Induced Structural Change in a Ca<sup>2+</sup> Regulatory Protein:  Ca<sup>2+</sup> and Troponin I Peptide Binding to the E41A Mutant of the N-Domain of Skeletal Troponin C","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Peptide; Conformational change; Biophysics; Binding site; Troponin C; Mutant; Binding domain; Dissociation constant; Troponin I; Stereochemistry; Crystallography; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002780291,0.0004262948,0.0004535652,0.0001484559,0.0006003235,0.0004615735,0.0006323375,0.0005612351,0.002189946],"category_scores_gemma":[0.0003659516,0.0002399519,0.0002616716,0.0001382946,0.0006960133,0.000289734,0.0002881305,0.0007503855,0.0002329896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007867998,"about_ca_system_score_gemma":0.0003039006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002697984,"about_ca_topic_score_gemma":0.001570088,"domain_scores_codex":[0.9997768,0.0000385087,0.000008556221,0.00004953928,0.00007188111,0.00005471483],"domain_scores_gemma":[0.9998185,0.00007634879,0.00003072694,0.000006916216,0.00001961482,0.00004786652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001538027,0.0003874171,0.003602311,0.0001628023,0.0001036394,0.000631719,0.0001947339,0.02024122,0.9670561,0.002173149,0.000566041,0.00334292],"study_design_scores_gemma":[0.0004224297,0.001591123,0.04591598,0.00003100419,0.0001081344,0.0007809534,0.0004427045,0.2750576,0.6710754,0.002027733,0.002365059,0.0001819217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988388,0.0001024874,0.0004099861,0.00005637935,0.000008830879,0.000005867371,0.00004639475,0.00001375485,0.0005175057],"genre_scores_gemma":[0.999033,0.0000744943,0.0003476673,0.00002828242,0.000003507793,0.00001029474,0.0001255592,0.00001441589,0.0003628996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002697984,"threshold_uncertainty_score":0.007326066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008583338336847077,"score_gpt":0.2214614887865045,"score_spread":0.2128781504496574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}